ABSTRACT
<p><b>OBJECTIVE</b>To observe pharmacological difference between ultra-fine particles of six ingredient Rehmannia pill and traditional six ingredient Rehmannia pill.</p><p><b>METHOD</b>Pharmacokinetic index was measured by death rate, and pharmacology actions were compared by anti-fatigue, hypoglycemic, clearance rate of charcoal particle, hypoxia resistance and serum hemolysin concentration experiment.</p><p><b>RESULT</b>Dose-effection was significant and pharmacology actions were more than traditional six ingredient Rehmannia pill in six ingredient Rehmannia pill.</p><p><b>CONCLUSION</b>Ultra-fine particles of six ingredient Rehmannia pill are better than traditional six ingredient Rehmannia pill in bioavailability and pharmacology actions, and the weight of pill is reduced while efficacy is enhenced by ultra-fine particles.</p>
Subject(s)
Animals , Male , Mice , Biological Availability , Drugs, Chinese Herbal , Pharmacokinetics , Pharmacology , Fatigue , Drug Therapy , Hemolysin Proteins , Blood , Hypoglycemic Agents , Pharmacology , Metabolic Clearance Rate , Plants, Medicinal , Chemistry , Powders , Rehmannia , ChemistryABSTRACT
<p><b>OBJECTIVE</b>To observe and study the tissue characteristics of T. mongolicum ultramicro-power and dissolving-out characteristics of effective compositions.</p><p><b>METHOD</b>By microscopic observation and thin-layer chromatography.</p><p><b>RESULT</b>Nearly all cell walls of T. mongolicum are broken and dissolving-out characteristics of effective compositions are remarkably improved, after it is ultramicro-porphyrized.</p>