ABSTRACT
Objective To investigate the reference intervals of lipid metabolism indexes and dyslipidaemia situation among the a-dult of Tibetan in Ganzi County .Methods The serum samples were collected from 661 healthy subjects in Ganzi county ,total cho-lesterol(TC) ,triglyceride(TG) ,high density lipoprotein cholesterol(HDL-C) ,low density lipoprotein cholesterol(LDL-C) ,apoli-poprotein A1(ApoA1) and apolipoprotein B(ApoB) levels were measured .According to the American Society for Clinical Laborato-ry Standards(CLSI) C28-A3 documentation and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) guidelines for establishing of reference interval with reasonable method and reliable basis ,the interval value of this lipid metabolism indexes were calculated .The dyslipidemia situation was analyzed based on "The Guideline of Prevention and Treatment of Dyslipi-demia in Chinese Adults in 2007".Results In these population ,TG ,LDL-C and ApoB in the serum of male were higher than those of female ,while HDL-C and ApoA1 were lower than those of female ,the difference was statistically significant (P<0 .05) .TC , LDL-C and TG level had a change tendency with ages obviously ,while the changes of HDL-C ,ApoA1 and ApoB metabolism level were not inconspicuous .In this population ,TC ,LDL and ApoB reference intervals were 2 .75 -6 .82 mmol/L ,1 .36 -4 .3 mmol/L and 0 .24-1 .38 mmol/L respectively .The reference interval of TG ,LDL-C and ApoA1 in male population were 0 .5-2 .36 mmol/L ,0 .9-1 .93 mmol/L and 0 .82-1 .87 mmol/L respectively ,meanwhile ,the reference range of TG ,HDL-C and ApoA1 in female population were 0 .47-3 .19 mmol/L ,0 .96-2 .19 mmol/L and 0 .94-2 .02 mmol/L respectively .The incidence of dyslipidemia in Tibetan adults was high ,the incidence of hypercholesterolemia ,hypertriglyceridemia ,mixed hyperlipidemia and low high-density lip-oprotein were 32 .07% ,21 .18% ,12 .86% and 6 .51% respectively .Conclusion In this research ,we established the reference inter-val of blood lipid metabolism indexes of Tibetan adults in Ganzi county and analyzed the incidence of hyperlipidemia in this popula-tion initially .This results provide reference data for clinical intervention treatment of patients with hyperlipidemia in Tibetan popu-lation in Ganzi area ,which is helpful for guiding the prevention and treatment of dyslipidemia in this region .
ABSTRACT
Objective To investigate the reference intervals of lipid metabolism indexes and dyslipidaemia situation among the a-dult of Tibetan in Ganzi County .Methods The serum samples were collected from 661 healthy subjects in Ganzi county ,total cho-lesterol(TC) ,triglyceride(TG) ,high density lipoprotein cholesterol(HDL-C) ,low density lipoprotein cholesterol(LDL-C) ,apoli-poprotein A1(ApoA1) and apolipoprotein B(ApoB) levels were measured .According to the American Society for Clinical Laborato-ry Standards(CLSI) C28-A3 documentation and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) guidelines for establishing of reference interval with reasonable method and reliable basis ,the interval value of this lipid metabolism indexes were calculated .The dyslipidemia situation was analyzed based on "The Guideline of Prevention and Treatment of Dyslipi-demia in Chinese Adults in 2007".Results In these population ,TG ,LDL-C and ApoB in the serum of male were higher than those of female ,while HDL-C and ApoA1 were lower than those of female ,the difference was statistically significant (P<0 .05) .TC , LDL-C and TG level had a change tendency with ages obviously ,while the changes of HDL-C ,ApoA1 and ApoB metabolism level were not inconspicuous .In this population ,TC ,LDL and ApoB reference intervals were 2 .75 -6 .82 mmol/L ,1 .36 -4 .3 mmol/L and 0 .24-1 .38 mmol/L respectively .The reference interval of TG ,LDL-C and ApoA1 in male population were 0 .5-2 .36 mmol/L ,0 .9-1 .93 mmol/L and 0 .82-1 .87 mmol/L respectively ,meanwhile ,the reference range of TG ,HDL-C and ApoA1 in female population were 0 .47-3 .19 mmol/L ,0 .96-2 .19 mmol/L and 0 .94-2 .02 mmol/L respectively .The incidence of dyslipidemia in Tibetan adults was high ,the incidence of hypercholesterolemia ,hypertriglyceridemia ,mixed hyperlipidemia and low high-density lip-oprotein were 32 .07% ,21 .18% ,12 .86% and 6 .51% respectively .Conclusion In this research ,we established the reference inter-val of blood lipid metabolism indexes of Tibetan adults in Ganzi county and analyzed the incidence of hyperlipidemia in this popula-tion initially .This results provide reference data for clinical intervention treatment of patients with hyperlipidemia in Tibetan popu-lation in Ganzi area ,which is helpful for guiding the prevention and treatment of dyslipidemia in this region .