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OBJECTIVE:To study the bioequiavailability of both the domestic and the imported azithromycin tablets in healthy human body.METHODS:The serum concentrations in 12 healthy volunteers was determined by HPLC-UV after administration of a single oral dose of 500mg azithromycin tablets by a cross-over design.The compartment model was discriminated by F-test and AIC method and the pharmacokinetic parameters were calculated by DAS program.RESULTS:The optimal compartment model fitted to two-compartment model.The main pharmacokinetics parameters of the domestic azithromycin tablets vs.the imported ones were the following:Cmax was(437.4 670? 51.5 670),(442.9 670? 61.5 030)? g/L;t1/2? was(44.7 450? 13.1 750),(49.2 670? 15.1 740)h;tmax was(2.5 830? 0.5 150),(2.5 830? 0.5 150)h;AUC0～ 144 was(13.2 799? 2.9 827),(12.1 953? 2.9 140)(mg? h)/L.The relative bioavailability of the domestic azithromycin tablets was(101.7? 0.1)%.CONCLUSION:The domestic azithromycin tablets and the imported ones were bioequivalent.
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OBJECTIVE:To explore the cleaning action of rhizoma pinelliae mi xture(RPM)on trachea secretions of the model animals.METHODS:The rats were divided randomly into high and low dose of RPM group and the control group;Then the secretion level of phenol red in each group was observed after the forming of models by tracheostomy and intraperitonal injection with phenol red;The respective time that spent on moving cork wood filings to a same distance by oral mucosa ep ?ithelium ciliary movement of toad both before and after medication were observed.RESULTS:The secretion level of phenol red in RPM group increased significantly compared with the control group(P
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0.05),and the costs were 441.28,436.63,543.55 and 437.89 yuan respectively,showing no significant difference compared among Group A,B and D,but the cost in Group C was 20% higher than in other groups.CONCLUSION: Scheme C is recommended only when scheme A,B and D are invalid(such as the patients are allergic to Amoxicillin or Furazolidone or resistant to Metronidazole).
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OBJECTIVE:To study the pharmacokinetics and the bioavailability of naftopidil sustained-release capsules. METHODS:Naftopidil capsule and sustained-release capsules were given to five healthy male dogs respectively in an open randomized cross-over test.Naftopidil concentrations in plasma were determined by HPLC method.The pharmacokinetics parameters and the relative bioavailability were measured and compared between naftopidil capsules and sustained-release capsules.RESULTS:A one-compartment open model with first-order absorption kinetics best fitted the concentration-time data.The T 1/2 ,AUC 0～∞ ,C max and T max of naftopidil capsule were3.2?1.1h,3728.1?573.1ng?h/ml,697.5?94.2ng/ml and1.2?0.59h,these pharmacokinetics parameters of sustained-release capsules were5.9?0.8h,5518.3?391.1ng?h/ml and468.6?61.3ng/ml and4.0?0.7h respectively.The relative bioavailability of naftopidil sustained-release capsules was149.8?14.4%when compared with naftopidil capsules.CONCLUSION:Naftopidil sustained-release capsules have satisfactory property in slow release of drug and much higher bioavailability than naftopidil capsules.