ABSTRACT
OBJECTIVE:To observe the clinical efficacy of Shengxuening tablets reducing the risk of microinflammation in maintenance hemodialysis(MHD)patients with renal anemia. METHODS:60 MHD patients were randomly divided into observa-tion group and control group with 30 cases in each group. The total dialysis times of all the patients were 12 h every week at blood flow of 200-250 ml/min and dialysis flow of 500 ml/min. Both groups received routine treatment;observation group was additional-ly given Shengxuening tablets orally 1.0 g,tid;control group was given ferrous succinate 0.2 g,tid,orally;both groups were giv-en subcutaneous injection of erythropoietin (EPO),10 000 IU/time,once a week;treatment for all of the patients lasted for 3 months. The fasting venous blood sample were collected at the beginning of treatment and in the morning every one months. The levels of hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor α(TNF-α),IL-6,hemoglobin(Hb),and hematocrit (Hct)were detected. RESULTS:After 3 months of treatment,total effective rate of 2 groups were 90.00%,the levels of hs-CRP、TNF-α、IL-6 in observation group were much lower than that before treatment and control group after treatment,with statistical sig-nificance(P<0.05 or P<0.01). No severe ADR was found in 2 groups,and the incidence of ADR in observation group(6.67%) was significantly lower than in control group (13.33%),with statistical significance (P<0.05). CONCLUSIONS:Shengxuening tablets have good curative effect,and they can reduce the risk of microinflammation due to the long-term use of EPO and chalybeate.
ABSTRACT
Cardiovascular disease is mainly referred to the artheriosclerosis which is caused by the interaction of multiple risk factors.Controlling for the risk factors can prevent its occurrence effectively.Primary prevention of cardiovascular disease is mainly to improve lifestyle and control all kinds of controllable risk factors positively.In addition to the causes,prevention and drug therapy are included in secondary prevention.
ABSTRACT
Ischemic stroke has the characteristics of high morbidity,high mortality and high disability rate,which brings to the society and family burden and pain.Therefore,effective prevention is especially important.Primary prevention of stroke is to prevent maiden stroke,mainly to improve lifestyle,and control all kinds of controllable risk factors positively.Secondary prevention of stroke is to prevent the recurrence of stroke,in addition to the causes,prevention,antiplatelet therapy,and anticoagulant therapy are included.