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Journal of the Medical Research Institute-Alexandria University. 1998; 19 (4): 152-165
in English | IMEMR | ID: emr-48264

ABSTRACT

Today the nucleolar organizer regions [NORS] have recently attracted much attention because of claims that frequency within the nuclei is significantly higher in malignant cells than in normal reactive or benign neoplastic cells. The present study included forty five cases. Eighteen cases were prospective and 27 were retrospective. They were grouped according to tile tumors 16 cases of mucinous tumors, 2 cases of Brenner tumors and 3 cases of endometroid carcinoma. The cases were stained by H and E and freshly prepared AgNORs solution. AgNORs appear as brown or black dots within the nucleus. There was no significant difference between benign and borderline serous tumors. But there was a significant difference between borderline and malignant serous carcinoma. Considering mucinous tumors, there was no significant difference in AgNOR count between benign and borderline mucinous tumors, however, a significant difference between benign and malignant mucinous tumors was demonstrated. Considering mucinous adenocarcinoma and endomatroid carcinomas after follow up of the cases, it was found that they had a better prognosis than those of serous adenocarcinomas. The AgNOR counts in these cases were also less than those of serous adenocarcinomas


Subject(s)
Humans , Female , Nucleolus Organizer Region , Retrospective Studies , Follow-Up Studies , Radiotherapy , Chemotherapy, Adjuvant
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