ABSTRACT
ObjectiveTo analyze the affection of salmeterol/fluticasone combined with bi-level positive airway pressure ventilation on lung function and life quality in treatment of chronic obstructive pulmonary disease (COPD) stable phase patients.MethodsOne hundred and four moderate and severe COPD stable phase patients were divided into two groups by random digits table with 52 cases each,Observation group were treated with salmeterol/fluticasone combined with bi-level positive airway pressure ventilation,and control group were treated with bi-level positive airway pressure ventilation.The lung function and life quality between two groups were compared.ResultsThe levels of forced expiratory volume in one second (FEV1),FEV]forced vital capacity (FVC) and 75 percent of forced expiratory flow(FEF75) after treatment were higher than those before treatment in obseration group[ (2.27 ± 0.45 ) L vs.( 1.55 ± 0.30) L,(69.12 ±7.71)％ vs. (55.65 ±5.11)％,(0.62 ±0.22) L/s vs. (0.31 ±0.13) Us] and control group [ ( 1.87 ± 0.39 ) L vs.( 1.56 ± 0.31 ) L,(62.79 ± 6.86 )％ vs.(55.69 ± 5.13 )％,(0.45 ± 0.18 ) L/s vs.(0.32 ± 0.14)L/s] with significant differences (P ＜0.05),and the levels of FEV1,FEV]FVC and FEF75 after treatment in observation group were higher than those in control group with significant differences(P ＜ 0.05 ).The scores of respiratory symptoms, activity limitation, disease impact and St.George respiratory questionnaire (SGRQ) total score after treatment were lower than those before treatment in observation group [(24.15 ±9.68) scores vs. (59.28 ± 17.70) scores,(21.39 ±7.43) scores vs. (44.15 ± 13.91) scores,(18.61 ± 6.39) scores vs. (46.54± 14.58) scores,(21.85 ± 8.14) scores vs.(48.86 ± 15.75) scores] and control group [ (42.36 ± 12.19) scores vs. (58.72 ± 17.65) scores,(36.28 ± 9.35) scores vs. (43.21 ± 13.46) scores,(29.35 ± 8.24) scores vs.(45.67 ± 14.29) scores,(33.69 ± 9.26) scores vs. (48.37 ± 15.42) scores] with significant differences (P ＜ 0.05),and the scores of respiratory symptoms,activity limitation,disease impact and SGRQ total score in observation group were lower than those in control group with significant differences (P＜0.05).ConclusionsSalmeterol/fluticasone combined with bi-level positive airway pressure ventilation in treatment of COPD stable phase can improve lung function,andenhance life quality,which can be applied in clinic.