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Objective@#To evaluate the efficacy of cognitive-behavioral therapy (CBT) combined with mirtazapine for patients with functional dyspepsia (FD).@*Methods@#Totally 121 patients with FD who met Rome Ⅳ diagnostic criteria in clinic of clinical psychiatry of a general hospital were collected.They were randomly divided into combined treatment group(n=61) and single drug group(n=60). The treatment period was 8 weeks.All patients with FD were given mirtazapine.The combined treatment group received 8 times systemic CBT treatments at the same time.Symptom checklist-90 (SCL-90) and gastrointestinal integral scale (GIS) were evaluated in all patients before and after 8-week intervention.@*Results@#After 8 weeks of intervention, the total score of SCL-90 scale, somatization, compulsion, depression, paranoia and other factors in the combined treatment group were lower than those in the single group(130.26±36.18 vs 147.95±45.55, 1.34±0.44 vs 1.51±0.5, 1.66±0.50 vs 1.90±0.66, 1.47±0.52 vs 1.69±0.63, 1.48±0.49 vs 1.70±0.61, 1.47±0.50 vs 1.73±0.68, respectively)(all P<0.05). After 8 weeks of intervention, the total score of the GIS scale in the combined treatment group (6.77±5.05 vs 9.49±5.24), vomiting (0.57±0.77 vs 0.88±0.91), spastic upper abdominal pain (0.43±0.74 vs 0.90±1.08) and post-sternal discomfort (0.57±0.89 vs 1.05±1.19) were significantly lower than that of the simple drug group after intervention(6.77±5.05 vs 9.49±5.24, 0.57±0.77 vs 0.88 ±0.91, 0.43±0.74 vs 0.90±1.08 and 0.57±0.89 vs 1.05±1.19, respectively), and the differences were statistically significant (all P<0.05).@*Conclusion@#CBT combined with mirtazapine in the treatment of FD is superior to drug therapy alone.CBT combined with mirtazapine can improve the emotional problems in the treatment of FD and further improving the digestive function.
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Objective To preliminarily develop a lifestyle self-assessment scale being suitable for patients with polycystic ovary syndrome (PCOS) and test its reliability and validity.Methods 98 patients with PCOS were surveyed by behavior questionnaire including somatic symptom,psychological behavior,life habits and social function.The lifestyle self-assessment scale for PCOS including 19 items was generated by factor analysis with cutting items and adjusting structure and tests of the reliability and validity.Then,40 patients with PCOS and 40healthy controls were surveyed to test the scale' discriminant validity.ResultsThe lifestyle self-assessment scale for PCOS was consisted by 19 items which generated 5 factors (each characteristic root ＞ 1,cumulative rate =56.625％ ).The Crunbach' sα was 0.626 ～ 0.826 and the intraclass correlation coefficient was 0.709 ～0.822.There were significant differences in three factors containing exercise consciousness,physique cognition and rhythm of life in the scale between PCOS and control group.Conclusion This scale accords with the living habits characteristics of PCOS patients and can provide guidance and basis for lifestyle intervention.
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Objectives To gain a deeper understanding of the role of the basal ganglia in implicit learning by examining Weather Prediction Category Learning Task among patients with basal ganglia stroke.Methods Seventeen patients with basal ganglia stroke including eight cases of left basal ganglia lesions and nine cases of right basal ganglia lesions.Ten cases without brain damage were used as contr0l.All of the subjects were tested by use of Weather Prediction Category Learning Task(WPCLT) and Wisconsin Card Sorting Test (WCST)in 3 consecutive days.Results The patients with right basal ganglia lesions were consistently impaired compared with the controls((52.72±5.57)%vs(61.85±8.49)%,F=3.55,P=0.048);(55.83±4.52)%vs(71.85±10.89)%,F=7.74,P=0.003);(62.33±7.70)%vs(80.15±6.67)%,F=10.96,P=0.001)),and the patients with right basal ganglia lesions were impaired in the last day(F=10.96,P=0.009).But in patients of left and right basal ganglia lesions,the learning potential of WPCLT decreased significantly compared with the control(P<0.01).In the control group,the WPCLT total number of correct and WCST Number of Categories Completed were hishly related in the second day.The WPCLT total number of correct correlated significantly with Percent Errors and Number of Categories Completed of WCST in the third day.Conclusion The basal ganglia lesions may decrease implicit learning,and the bottom-up(implicit-to-explicit)learning pattern is impaired in patients with basal ganglia lesions.