ABSTRACT
Objective@#To reveal clinical features, pathological diagnosis, treatment and prognosis of primary thymic mucosa-associated lymphoid tissue (MALT) lymphoma and review literatures.@*Methods@#The clinical characteristics, pathological diagnosis, laboratory texts, treatment and prognosis of 7 cases of primary thymic MALT lymphoma identified at the First Affiliated Hospital of Nanjing Medical University from November 2017 to January 2019 were collected and analyzed.@*Results@#Of 7 primary thymic MALT lymphoma cases, six were female. Patients were often asymptomatic and were found mediastinal mass by chest CT. After mediastinal mass resection, pathologist reported a primary thymic MALT lymphoma. Laboratory tests showed all patients were positive for anti-nuclear antibody, anti-Ro52 antibodies and anti-Sjogren’s syndrome A antibodies, and increased erythrocyte sedimentation rate (ESR) . Four were diagnosed with Sjogren’s syndrome (SS) . After surgery, the patients were given the positron emission tomography computed tomography (PET-CT) scans. All cases received "watch and wait" approach. Up to now, all cases showed good prognoses and none of them relapsed.@*Conclusion@#Primary thymic MALT lymphoma was rare, and it was often associated with autoimmune diseases. Such patients who usually had good prognoses should be followed up closely and avoided excessive treatments if there were no indications of intervention.
ABSTRACT
Follicular lymphoma (FL) is a kind of indolent non-Hodgkin lymphoma deriving from follicle germinal center. Relapsed and refractory FL usually requires multiline treatments. With the great advance of novel drugs and a large number of clinical trials, the treatment model of FL has been changing continually. High dose therapy combined with hematopoietic stem cell transplant could provide preferable remissions for FL patients. Meanwhile, as more and more clinical trials have made great progress, novel drugs including inhibitors of PI3K, programmed death-1 (PD-1) or lenalidomide and antibody radionuclide conjugate have brought an increasing options for FL treatment.