ABSTRACT
Objective To investigate the influence of warfarin anticoagulation intensity on curative effect and prognosis in patients with non valvular atrial fibrillation in elderly patients with stable coronary heart disease .Methods From February 2012 to March 2014,96 elderly patients with stable coronary heart disease and non valvular atrial fibrillation in the Second People's Hospital of Yuyao were randomly divided into study group ( low intensity warfarin therapy) and control group(warfarin therapy) according to the digital table,with 48 cases in each group.The patients were followed up for average 2 years after treatment ,the condition of taking drugs ,major secondary end point ,end point and safety were compared between the two groups .Results The INR and warfarin dosage of the study group were lower than those of the control group [(1.71 ±0.38) vs.(2.37 ±0.36),(2.72 ±0.28) mg/d vs.(3.54 ± 0.34)mg/d],the differences were statistically significant (t＝8.736,12.898,all P＜0.05),there were no statistically significant differences in other drugs use between the two groups (χ2＝0.178,0.066,0.344,0.071,0.545,0.042, 0.066,all P＞0.05).There were no statistically significant differences in ischemic stroke and body circulation embolism rate between the two groups (χ2＝0.000,0.211,0.211,0.000,0.000,0.000,0.000,1.011,0.000,all P＞0.05). There were no statistically significant differences in end point of all －cause death or nonfatal myocardial infarction incidence between the two groups (χ2＝1.011,0.000,0.000,0.211,0.000,0.000,0.000,0.211,all P＞0.05). The mild bleeding and total bleeding rate of the study group were lower than those of the control group (2.08% vs. 12.50%,4.16%vs.18.75%),the differences were statistically significant (χ2＝3.852,5.031,all P＜0.05).There was no statistically significant difference in the rate of major bleeding events between the two groups (2.08% vs. 6.25%,χ2＝1.043,P ＞0.05).Conclusion The low intensity and moderate intensity warfarin anticoagulation therapy has similar efficacy for elderly patients with stable coronary heart disease and non valvular atrial fibrillation, but low intensity warfarin anticoagulation therapy is safer .
ABSTRACT
Objective To analysis the effect of paclitaxel on CEA, CA19-9 and CA72-4 levels in patients with advanced gastric cancer.Methods46 patients who were diagnosed with advanced gastric cancer in Pinghu hospital of traditional Chinese medicine were collected.All patients were randomly divided into experimental group and control group,23 cases in each group.The control group was treated with cis-platinum complexes and capecitabine, and the experimental group was treated with paclitaxel and capecitabine, after the treatment, the serum levels of CEA, CA19-9, CA72-4, vascular endothelial growth factor, endostatin and clinical curative effect were detected in all patients.ResultsAfter treatment, compared with control group,①the serum level of CEA was lower in the experimental group (P<0.05);②the serum level of CA19-9 and CA72-4 were lower in the experimental group (P<0.05);③the serum level of VEGF was lower in the experimental group (P<0.05);④the serum level of Endostatin was higher in the experimental group (P<0.05);⑤The clinical efficiency of the experimental group was higher(P<0.05).ConclusionsThe paclitaxel can significantly reduce the serumCEA, CA19-9, CA72-4 and VEGF levels, elevated serum Endostatin level in patients with advanced gastric cancer, improve the treatment effect, and have a guiding significance for clinica.