ABSTRACT
Objective:To investigate the effects of the timing of chemotherapy after breast cancer surgery on patient's immune function and quality of life.Methods:A total of 100 patients who underwent modified radical mastectomy for breast cancer from January 2017 to January 2019 in Jining No. 1 People's Hospital were included in this study. These patients were randomly divided into a control group and an early chemotherapy group ( n = 50/group). Patients in the control group underwent chemotherapy 4-6 weeks after surgery. Patients in the early chemotherapy group received chemotherapy 2 weeks after surgery. The chemotherapy regimens were the same in the two groups. The levels of CD 4+, CD 8+, CD 4+/CD 8+, immunoglobulin A (IgA), and immunoglobulin G (IgG) were measured before and after chemotherapy in each group. Chemotherapy-related reverse reactions and infections were recorded. The quality of life was evaluated in each group at the last follow-up. Results:Before chemotherapy, there were no significant differences in CD 4+, CD 8+, CD 4+/CD 8+, IgA, and IgG levels between the two groups (all P > 0.05). After chemotherapy, CD 4+ and CD 4+/CD 8+ levels in the early chemotherapy group were (51.76 ± 5.21)% and (2.00 ± 0.25), respectively, which were significantly higher than (48.21 ± 4.78)% and (1.70 ± 0.21) in the control group ( t = 3.55, 4.98, both P < 0.05). After chemotherapy, the CD 8+ level in the early chemotherapy group was (25.93±2.43)%, which was significantly lower than (28.29 ± 2.31)% in the control group ( t = 6.50, P < 0.05). Serum IgA and IgG levels in the early chemotherapy group were (3.24 ± 0.38) g/L and (9.27 ± 1.04) g/L, respectively, which were significantly higher than (2.75 ± 0.37) g/L and (8.43 ± 0.97) g/L in the control group ( t = 6.53, 4.18, both P < 0.05). During chemotherapy, there was no significant difference in the incidence of reverse reactions between the two groups (all P > 0.05). The incidence of infections was significantly lower in the early chemotherapy group than the control group ( P < 0.05). At the last follow-up, generic quality of life inventory-74 scores in the early chemotherapy group were significantly higher than those in the control group (all P < 0.05). Conclusion:Early chemotherapy can markedly reduce the effects of chemotherapy on the immune function of patients after breast cancer surgery, decrease the incidence of infections, and improve quality of life.
ABSTRACT
Objective To investigate the expression of serum thymidine kinase-1 (TK1) and its relationship with clinical and pathological features in patients with mammary gland invasive ductal carcinoma (MGIDC),and the rde of TK1 in the invasion and progression of MGIDC.Methods The clinical data of 60 patients with MGIDC who underwent surgical treatment were retrospectively analyzed,the healthy subjects were considered as control group.The serum TK1 level was detected by chemiluminescence combined with dot blot hybridization.Results The TK1 positive expression rate of breast cancer group was 75.0％,compared with the the control group (6.7％) the difference between the two groups was significant(x2 =23.155,P ＜ 0.05).The TK1 positive expression rate of the tumor diameter ≥5cm group,the TNM stage Ⅲ to Ⅳ group and lymph node metastasis group was significantly higher than the tumor diameter ＜5cm group,the TNM stage Ⅰ to Ⅱ group and without lymph node metastasis group,the difference was significant(P ＜ 0.05).The TK1 positive expression rate was not statistically significant between the different age group and degree of tumor differentiation group (P ＞ 0.05).Conclusion The serum TK1 is high expression in patients with MGIDC,the serum TK1 level is closely related to the tumor size,TNM stage and lymph node metastasis.The high expression of serum TK1 shows the invasion and progression of MGIDC.