ABSTRACT
Background: Multidrug-resistant Enterococci are major problem and are increasingly reported worldwide. Enterococcal infections have been associated with higher hospitalization costs and a higher number of related deaths. Treatment of multidrug-resistant enterococci has become a challenge in hospitals around the world due to the lack of reliable therapeutic options. So the present study was undertaken with the aim to know the antimicrobial resistantpattern of enterococcus to newer antibiotic. Methodology: 22 isolates of enterococcus resistant to the entire routinely tested antibiotic were further tested for newer antimicrobial agent linezolid, daptomycin, rifampin, synercid, teicoplanin, telavancin, vancomycin, gentamicin (HLG). Results: Among these 22 enterococci isolated none of our isolates showed resistance to vancomycin, teicoplanin, telavancin, tigecycline and linezolid. But one isolate of E.faecalis showed resistance to daptomcyin. This daptomycinnonsusceptible isolate was found susceptible to ceftaroline. E. faecalis showed higher resistance to Gentamicin (HLG) and Synercid as compared to E.faecium. Specimen-wise higher distribution of enterococci (resistant to routinely tested antimicrobial agents) was observed in Urine 11(50%) followed by Pus 4(18.18%) and Miscellaneous 4(18.18%) and from Blood 3(13.64%). Conclusion: In our study none of the isolates showed resistance to vancomycin, tigecycline, telavancin, linezolid and ceftaroline but thepresence of daptomycin non-susceptible enterococci 1(4.55%) in our rural set-up is cause of concern.
ABSTRACT
Abstracts: Background: Wound infections are one of the most common hospital acquired infections and are an important cause of morbidity and account for 70-80% mortality. Pseudomonas aeruginosa is an epitome of opportunistic nosocomial pathogen & responsible for serious infection such as septicemia ,pneumonia ,various pyogenic & wound infections. Pseudomonas aeruginosa is inherently resistant to many antibiotics and can mutate to even more resistant strains during therapy. So the present study aimed to find out the strains of Pseudomonas aeruginosa from various pyogenic & wound infections, their antibiotic sensitivity profile & to find out multidrug resistant strains. Methodology: Pseudomonas aeruginosa isolates obtained from pyogenic & wound infection samples were identified by conventional microbiological techniques. All these isolates were tested for antimicrobial susceptibility on Muller-Hinton’s agar by Kirby-Bauer disk diffusion method as per CLSI guidelines. Results: Out of 90 Pseudomonas aeruginosa strains,49 (54.44 %) were MDR strains & highest sensitivity was found to levofloxacin (74.44 %) ,amikacin, (67.77%),cefepime(65.55 %), pipercillin (64.4%) & ceftazidime (63.33 %). Conclusion: The prevalence of MDR strains in our study is 54.4 % which calls for the judicious selection of antibiotics in clinical practice. In addition, regular antimicrobial susceptibility surveillance is essential for area-wise monitoring of the resistance patterns. An effective national and state level antibiotic policy and draft guidelines should be introduced to preserve the effectiveness of antibiotics and for better patient management.
ABSTRACT
We report a rare case of Hymenolepis diminuta infection in a 12-year-old girl from a rural area of Devghar.