A comparative study on the effect of felodipine and propranolol on serum lipid profile of rabbits.

Effect of felodipine on serum lipids of rabbits was studied and was compared with that of propranolol. Lipid parameters were estimated at basal (0 wk), end of 4th and 16th week of diet/drug administration by using standard kits for analysis. There was a significant increase in mean serum cholesterol, TG, VLDLc, LDLC and decrease in HDLc, (P<0.05) in the group of rabbits receiving Atherogenic diet (AD)/Propranolol. This effect was maximally observed in rabbits receiving both AD and propranolol. This change was satisfactorily prevented when felodipine was administered from very beginning (P<0.001). In addition, there was a significant increase in HDLc (28.89%) of rabbits receiving felodipine from beginning. Thus both AD and propranolol have dyslipidemic effect and early administration of felodipine favorably changes all lipid parameters.

Temperature-absorption transition spectroscopy: a technique for estimating the relative charge densities on thiolated phosphate groups in nucleic acid analogues.

Various polynucleotides with well-defined sequences at low salt concentration have been studied using temperature-absorbtion transition spectroscopy to understand their conformations. It has been observed that the adopted technique can fairly estimate the relative charge densities at the thiolated phosphate groups in nucleic acid analogues at low salt concentrations.