ABSTRACT
Objective@#The aim of this study was to explore the effects of 2-hexyl-4-pentylenic acid (HPTA) in combination with radiotherapy (RT) on distant unirradiated breast tumors.@*Methods@#Using a rat model of chemical carcinogen (7,12-dimethylbenz[a]anthracene,DMBA)-induced breast cancer, tumor volume was monitored and treatment response was evaluated by performing HE staining, immunohistochemistry, immunofluorescence, qRT-PCR, and western blot analyses.@*Results@#The results demonstrated that HPTA in combination with RT significantly delayed the growth of distant, unirradiated breast tumors. The mechanism of action included tumor-associated macrophage (TAM) infiltration into distant tumor tissues, M1 polarization, and inhibition of tumor angiogenesis by IFN-γ.@*Conclusion@#The results suggest that the combination of HPTA with RT has an abscopal effect on distant tumors
Subject(s)
Animals , Female , Rats , Antineoplastic Agents/therapeutic use , Cell Proliferation/radiation effects , Combined Modality Therapy , Cytokines/immunology , Fatty Acids, Unsaturated/therapeutic use , Mammary Neoplasms, Experimental/radiotherapy , Tumor-Associated Macrophages/radiation effectsABSTRACT
No abstract available.
ABSTRACT
No abstract available.