ABSTRACT
Prevalence of hypothyroidism and its subsequent cardiometabolic complications is on exponential rise. CRP is raised in hypothyroid patients long before other metabolic derangements of hypothyroidism take place and may be a common Patho physiological factor tying together various components of cardiometabolic dysfunction. Present study was aimed at evaluating the role of CRP as an additional cardiovascular risk marker in hypothyroid patients. Methods: 46 diagnosed hypothyroid patients and 46 age and sex matched healthy controls were included in this study. Participants were evaluated based on detailed history, clinical examination and laboratory investigations. Blood samples were collected after overnight fast. Serum T3, T4, TSH, Total Cholesterol (TC), Triglycerides (TG), HDL Cholesterol (HDL-C), VLDL Cholesterol (VLDL-C), LDL Cholesterol (LDL-C) and CRP were estimated. Results were analyzed by unpaired t-test, P-value was determined & Correlation coefficient was calculated amongst various parameters. Results: Statistically significant increased levels of serum TSH, total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, VLDL cholesterol and CRP in hypothyroid patients as compared with control were observed. We found decreased levels of serum T3 and T 4 in hypothyroid patients as compared with control. Conclusions: An atherogenic lipid profile along with inflammation in patients with hypothyroidism predispose them to cardiovascular disease. Study suggests CRP; a simple, sensitive & independent cardiovascular risk predictor in hypothyroid patients with a potential to reveal hidden burden of metabolic dysfunction and offers a hope that, cardiovascular event can be well prevented with appropriate interventions.
ABSTRACT
Background: Hypertension is a common, asymptomatic, readily detectable disease that leads to lethal complications if left untreated. Vascular inflammation may be involved in both the initiation and development of hypertension that is evident from the elevated levels of inflammatory markers like Tumor necrosis factor-α, Interleukin-6 and C-reactive protein (CRP) found in people with hypertension with no evidence of cardiovascular disease. hsCRP is associated with an increased risk of incident hypertension at all baseline blood pressures and among individuals without traditional coronary heart disease risk factors. Objectives: The present cross-sectional study was an attempt to evaluate the relationship of serum hsCRP levels and serum Lipid profile in prehypertensives and hypertensive. Material & methods: The study group included thirty diagnosed cases of prehypertension and hypertension each, attending medicine OPD at a tertiary care hospital. A healthy group of normotensive volunteers were taken as controls. Fasting blood samples were collected for measurement of serum lipid profile and hsCRP (by CLIA).Results: There was statistically significant rise in hsCRP levels in hypertensives as compared to controls and normotensives (p<0.001). The concentration of cholesterol, triglycerides and LDL-C were significantly high in hypertensives as compared with normotensives (p<0.001). Conclusion: Findings of higher levels of hsCRP in hypertension along with atherogenic lipid profile suggests that elevated hsCRP and hypertension can be independent determinants of cardiovascular risk.