Progress in Combination Therapy to Infection of Carbapenem-Resistant Pseudomonas aeruginosa / 中国药学杂志

The outbreak of carbapenem-resistant Pseudomonas aeruginosa has been continuously reported in hospitals worldwide. The infection caused by carbapenem-resistant Pseudomonas aeruginosa increased the therapy failure and mortality, the effective antibiotics against carbapenem-resistant Pseudomonas aeruginosa are limited, and combination therapy is often recommended to treat CRPA infection. To fully master the advance on combination therapy of CRPA infection, and provide a theoretical basis for the rational use of the combination therapy, this article reviewed the synergistic effect in vitro or in vivo and clinical study of antimicrobial agents treating CRPA infection.