ABSTRACT
OBJECTIVE: To explore changes of biochemical indicators in maintenance hemodialysis patients in the last year of their survival.METHODS: Maintenance hemodialysis patients died from January 1, 2008 to December 31, 2017 were screened for enrollment. They were divided into two groups according to the cause of death: CCVD group and non-CCVD group. For the enrolled patients, biochemical indexes were performed every 3 months within one year before the end of life. RESULTS: A total of 145 cases(80 males, 65 females, median age of death at age 71) were included. Patients were divided into two groups according to the causes of death: 74 cases died of cardio-cerebrovascular diseases(CCVD group) and 71 cases died of non-cardio-cerebrovascular diseases(non-CCVD group). Serum albumin and creatinine concentration were maintained at high levels in the CCVD group and serum phosphorus increased one month before death. The serum calcium compliance rate in the CCVD group was significantly lower than that in the non-CCVD group at 9 months and 6 months before death. The proportion of patients with serum calcium >2.5 mmol/L at 12 th-6 th month before death and with serum phosphorus >1.78 mmol/L at 6 th-1 st months before death was higher than that of non-CCVD group. Serum albumin and creatinine concentration remained lower level and the later decreased early and significantly in the non-CCVD group. The proportion of patients with serum phosphorus <1.13 mmol/L was higher than that of the CCVD group at 3 months and one month before death. Serum albumin in patients who died from infective diseases began to decline significantly at the time of 6 months before death and decreased by 8.57% during 6 months. Serum albumin was consistently lower than 38 g/L and 36 g/L in patients who died from cachexia syndrome and tumor respectively in the last year before death. CONCLUSION: Serum creatinine concentration, serum calcium, serum phosphorus,serum albumin and other indicators of MHD patients with different death causes within the last year of survival presented characteristic changes.