ABSTRACT
Objective To investigate the epidemiological characteristics and its associated risk factors of lower urinary tract symptoms in young Chinese obese males.Methods A total of 126 young males aged 20-40 years admitted to Beijing Friendship Hospital,Capital Medical University were enrolled into two different groups in this study,including 74 obese patients visited metabolic weight loss clinic were included in the experimental group,and 52 conditionally healthy persons were included in the control group.Blood pressure (systolic blood pressure,diastolic blood pressure),insulin resistance (fasting blood glucose,insulin,C-peptide),blood lipid metabolism (triglycerides,high-density lipoprotein cholesterol),and sex hormones (estrogen) of the two groups of subjects.Hormones,serum testosterone),C-reactive protein (CRP),International prostate symptom score (IPSS) and quality of life score (QOL).were compared between the two groups of subjects.Comparisons of measurement data between groups were statistically analyze by t test,expressed by mean ± standard deviation (Mean ± SD);the correlation between body mass index and LUTS was analyzed by Spearman rank correlation,and the risk factors of LUTS and clinical variables were analyzed by univariate logistic regression.The significant variables were analyzed by multivariate logistic regression.Results There were significant statistical differences between experimental group and control group in terms of systolic blood pressure [(144.30 ± 15.78) mmHg vs (125.9 ±66.11) mmHg,P＜0.001],diastolic blood pressure [(89.46 ± 12.76) mmHg vs (81.35 ±4.58) mmHg,P =0.001],and fasting blood glucose [(6.73 ± 3.15) mmol/L vs (5.26 ± 1.47) mmol/L,P =0.016],insulin [(26.60 ± 19.09) mg/dLvs (13.43 ±7.68) mg/dL,P＜0.001],C-peptide [(4.20±1.73) ng/mL vs (1.59 ± 0.52) ng/mL,P=0.001],triglycerides [(2.42 ± 1.88) mg/dL vs (1.45 ± 0.79) mg/dL,P =0.007),estrogen [(52.32±21.77) ng/L vs (42.11 ± 12.19) ng/L,P =0.023] and CRP [(6.49±4.96) mg/L vs (1.62 ±1.53) mg/L,P =0.037],but no statistical difference regarding high-density lipoprotein [(1.10 ± 0.55) mg/dL vs (1.06 ±0.26) mg/dL,P =0.669] and serum testosterone [(275.00 ± 100.68) ng/dL vs (280.28 ± 85.52) ng/dL,P =0.823].In addition,the experimental group had higher IPSS [(3.81 ± 1.88)scores vs (0.69 ±0.30) scores,P ＜0.001] and QOL scores [(2.76 ±0.68) scores vs (0.12 ±0.08) scores,P＜0.001] than the control group,and higher risk of LUTS [86.49％ vs 42.31％,P ＜ 0.001],especially moderate LUTS (21.62％ vs 0,P =0.011).Spearman rank correlation analysis showed that obesity (body mass index≥30 kg/m2) was significantly associated with moderate LUTS risk (r =0.407,P ＜ 0.001);Univariate logistic regression analysis showed that systolic blood pressure,insulin,and C-peptide were important risk factors of moderate LUTS in young obese patients (P =0.009,0.029,0.002).Systolic blood pressure and fasting C-peptide were independent risk factors by multivariate logistic regression analysis (P =0.011,0.003).Conclusions The middle severity of LUTS was prevalent in young obese males,and systolic blood pressure and C-peptide were its significant independent risk factors.
ABSTRACT
Objective@#To investigate the epidemiological characteristics and its associated risk factors of lower urinary tract symptoms in young Chinese obese males.@*Methods@#A total of 126 young males aged 20-40 years admitted to Beijing Friendship Hospital, Capital Medical University were enrolled into two different groups in this study, including 74 obese patients visited metabolic weight loss clinic were included in the experimental group, and 52 conditionally healthy persons were included in the control group. Blood pressure (systolic blood pressure, diastolic blood pressure), insulin resistance (fasting blood glucose, insulin, C-peptide), blood lipid metabolism (triglycerides, high-density lipoprotein cholesterol), and sex hormones (estrogen) of the two groups of subjects. Hormones, serum testosterone), C-reactive protein (CRP), International prostate symptom score (IPSS) and quality of life score (QOL). were compared between the two groups of subjects. Comparisons of measurement data between groups were statistically analyze by t test, expressed by mean ± standard deviation (Mean±SD); the correlation between body mass index and LUTS was analyzed by Spearman rank correlation, and the risk factors of LUTS and clinical variables were analyzed by univariate logistic regression. The significant variables were analyzed by multivariate logistic regression.@*Results@#There were significant statistical differences between experimental group and control group in terms of systolic blood pressure [(144.30±15.78) mmHg vs (125.9±66.11) mmHg, P<0.001], diastolic blood pressure [(89.46±12.76) mmHg vs (81.35±4.58) mmHg, P=0.001], and fasting blood glucose [(6.73±3.15) mmol/L vs (5.26±1.47) mmol/L, P=0.016], insulin [(26.60±19.09) mg/dL vs (13.43±7.68) mg/dL, P<0.001], C-peptide [(4.20±1.73) ng/mL vs (1.59±0.52) ng/mL, P=0.001], triglycerides [(2.42±1.88) mg/dL vs (1.45±0.79) mg/dL, P=0.007), estrogen [(52.32±21.77) ng/L vs (42.11±12.19) ng/L, P=0.023] and CRP [(6.49±4.96) mg/L vs (1.62±1.53) mg/L, P=0.037], but no statistical difference regarding high-density lipoprotein [(1.10±0.55) mg/dL vs (1.06±0.26) mg/dL, P=0.669] and serum testosterone [(275.00±100.68) ng/dL vs (280.28±85.52) ng/dL, P=0.823]. In addition, the experimental group had higher IPSS[(3.81±1.88) scores vs (0.69±0.30) scores, P<0.001] and QOL scores [(2.76±0.68) scores vs (0.12±0.08) scores, P<0.001] than the control group, and higher risk of LUTS [86.49% vs 42.31%, P<0.001], especially moderate LUTS ( 21.62% vs 0, P=0.011). Spearman rank correlation analysis showed that obesity (body mass index≥30 kg/m2) was significantly associated with moderate LUTS risk (r=0.407, P<0.001); Univariate logistic regression analysis showed that systolic blood pressure, insulin, and C-peptide were important risk factors of moderate LUTS in young obese patients (P=0.009, 0.029, 0.002). Systolic blood pressure and fasting C-peptide were independent risk factors by multivariate logistic regression analysis (P=0.011, 0.003).@*Conclusions@#The middle severity of LUTS was prevalent in young obese males, and systolic blood pressure and C-peptide were its significant independent risk factors.