ABSTRACT
Objective To investigate the differences of the characteristic and syndrome of patients with alcoholic cirrhosis(AC) and viral cirrhosis(VC).Methods Seventy patients with AC and 300 patients with VC in the Binzhou People's Hospital were selected as our subjects.The information including gender,age,disease history,chnical syndrome were collected.Meanwhile,the levels of Aspartate aminotransferase/alanine aminotransferase (AST/ALT),γ-glutamyl transferase (γ-GT),alkaline phosphatase (ALP) and total bilirubin (TBil) in serum were measured.Results The proportion of males in the AC group was 91.43％ (64/70),significantly higher than that of VC group(64％ (192/300),x2 =15.76,P =0.003)).The age,disease periods in AC group were (50.13 ± 12.35) years old and (2.09 ± 0.67) years,lower than the VC group ((58.66 ± 7.45) yearsold,t =3.97,P =0.042 ; (4.56 ± 1.14) years,t =5.22,P =0.034).There was no significant difference regarding of liver function index (P ＞ 0.05).The rate of nasal carp (18.57％),gum bleeding (27.14％),liver palms(64.29％),spider(45.71％) in the AC group were significantly higher than the VC group (6.33％,15.00％,47.00％,29.67％ respectively,P =0.017,0.036,0.025,0.016 respectively).The ratio of splenomegaly and esophageal varices were (81.43％) and (65.71％) in AC group,significantly lower than VC group (90.33％,86.00％ respectively,P =0.037,0.011 respectively).The cirrhosis laboratory parameters results showed AST/ALT ratio (1.97 ± 0.45),gamma-GT ((152.33 ± 23.41) U/L),ALP indicators ((232.46 ±35.16) U/L in AC group patients,which were significantly higher in the VC group(1.00± 0.22,(45.89 ± 11.23) U/L and (102.23 ± 21.78) U/L,P =0.035,0.011,0.007 respectively).Conclusion There are difference in term of characteristic,manifestations and the testing laboratory indicators between alcoholic cirrhosis and viral cirrhosis.
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Objective To investigate the correlation factors of liver injury in infectious mononucleosis(IM).Methods One hundred and seventy-five IM patients were divided into two groups:IM with liver injury(patient group,85 cases)and IM without liver injury(control group,90 cases).Single factor and multiple factor analysis were completed by unconditional Logistic regression.Results Single factor analysis results showed that there were significance differences between the two groups in age(≥6 years old),male,course of disease,severe disease(involving ≥ 2 organs),heating time,the peak temperature,white blood cell(WBC)and C reactive protein(CRP),CD4+,CD8+,CD4+/CD8+,Epstein-Barr virus(EBV)-capsid antigen(CA)-IgM antibody positive and increased erythrocyte sedimentation rate(ESR)(P＜0.05).Age(≥ 6 years old),male,course of disease,severe disease(involving ≥2 organs),heating time,the peak temperature,WBC,CRP,CD8+,EBV-CA-IgM antibody positive and increased ESR showed positive correlation with IM combined with liver injury,and CD4+,CD4+/CD8+ showed negatively correlated with IM combined with liver injury.Multiple factor analysis results showed that severe disease(involving ≥2 organs),CD8+ high levels were independent risk factors for IM combined with liver injury,and CD4+ high levels and CD4+/CD8+ high were protection factors for IM combined with liver injury(P＜0.05).Conclusions Severe disease(involving ≥2 organs),CD8+ high levels are independent risk factors for IM combined with liver injury,and CD4+ high levels and CD4+/CD8+ high are protection factors for IM combined with liver injury.Therefore,immune modulators should be used to intervene the above factors when patients are treated with antiviral drugs.
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Objective To investigate influence of nursing intervention on quality of life of hospitalized patients with peptic ulcer. Methods l00 cases of peptic ulcer patients from October 2009 to September 2011 were chosen as the object.50 patients of hospitalized patients were defined as the ward group,and 50 cases of patients in outpatient were defined as the outpatient group.The life quality questionnaire was adopted to evaluate life quality before and after treatment between two groups. Results After intervention,number of patients whose score ranged 5～7 grades were more in the ward group than those in the outpatient group. Conclusions Nursing intervention for patients with peptic ulcer has significant effect on life quality and treatment effect of them.