ABSTRACT
OBJECTIVE@#To study the change of laryngeal carcinoma cell apoptosis before and after radiotherapy.@*METHOD@#Living tissue of diseased region obtained from 27 cases of laryngeal carcinoma before and during radiotherapy 10, 30 and 60 Gy were used in this study. With terminal deoxynucleotidyl transferase mediated dUTP biotin nick end labeling (TUNEL), the spontaneous and radiation-induced apoptotic rate (AR)were examined.@*RESULT@#The AR of living tissue of laryngeal carcinoma before and during radiotherapy 10, 30 and 60 Gy were (21.0 +/- 0.7)%, (60.0 +/- 1.5)%, (42.0 +/- 1.3)%, (25.0 +/- 1.9)%, respectively. The radiation-induced apoptotic rate was significantly higher than that of spontaneous apoptotic rate (P< 0 . 5). In laryngeal carcinoma, spontaneous apoptosis was positively correlated with the radiation-induced apoptosis.@*CONCLUSION@#Detecting of AR of laryngeal carcinoma cells before and during radiotherapy may be helpful to predict the sensitivity of radiotherapy in laryngeal carcinoma patients.
Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Apoptosis , Radiation Effects , Carcinoma, Squamous Cell , Pathology , Radiotherapy , Dose-Response Relationship, Radiation , In Situ Nick-End Labeling , Laryngeal Neoplasms , Pathology , RadiotherapyABSTRACT
Objective To research special signs of MRCP,its pathological and clinical significance in carcinoma of pancreatic head.Methods 35 patients with pancreatic head carcinoma confirmed by operation and /or pathology were examined by MR before operation,including SE sequences T_1WI,FSE sequences T_2WI,T_2WI FS and MRCP.Results The special signs of MRCP in pancreatic head cancer were showed in all cases(100%),these signs included:type C1+P1 in 31 cases,type C2+P1 in 2 cases and type C2+P2 in 2 cases.The volumes of pancreatic cancer shown by MRCP were bigger than ones in operated.Conclusion MRCP features of carcinoma of pancreatic head are special.
ABSTRACT
pseudomonas pneumonia is a common and serious complication in neurosurge-ry. Its prognosis is poor and mortality high.The therapeutic effect of EP on 9 cases of pseudomonas pneumonia was studied from Sep. 1979 to Nov. 1981. The satisfactory results obtained were: the fever was lowered, the expectoration diminished, the antibody titer raised,the other symptoms and signs improved, and the bacterial culture converted negative.The results indicate that EP has some therapeutic value on pseudomonas pneumonia which is insensitive to most antibiotics.