ABSTRACT
Objective: To evaluate the efficacy and toxic reactions of Endostar combined with TP chemo-therapy in the treatment of advanced stage non-small cell lung cancer (NSCLC). Methods: A total of 68 cases of advanced stage NSCLC confirmed by pathohistology or cytology were randomly divided into two treate-ment groups: the Endostar combined with TP chemotherapy group (37 cases) and the simple TP chemothera-py group (31 cases). Patients in the Endostar combined with TP chemotherapy group were treated with TXT 65mg/m~2 on d2 and d9, DDP 75 mg/m~2, d1-4; and endostar 15g, d1-14. Patients in the simple chemotherapy group were treated with TXT and DDP. After 2 weeks, we estimated the recent curative effect and toxic reac-tions according to WHO standard. Results: The total response rates in the two groups were 56.8% and 29.7%, respectively, with a significant difference (X~2=4.08, P<0.05). The main toxic reactions were bone marrow sup-pression, gastrointestinal reactions and hair loss. And the incidences of the above three toxic reactions were 59.4%, 39.1%, and 81.1% in the endostar combined with chemotherapy group and 64.5%, 38.7%, and 83.9% in the simple chemothotherapy group. The toxic reactions were mainly related to chemotherapeutics and were not significantly different between the two groups (P>0.05). Conclusion: Endostar combined with chemothera-py is a safe method to treat advanced stage NSCLC. Endostar can improve the curative effect of chemothera-py. This method deserves to be clinically practiced and observed further.
ABSTRACT
24 white big ear female rabbits were divided into 3 groups at random, i. e. control group (CG), fever group (FG) and electric acupuncture group (EAG). CG were not given any treatment. Endotonin (ET) was i. v. injected into animals of FG and fever ensued. 80 min after the injection ET the body temperature of the animals raised 1.18℃. 80 min after the ET injection into animals of EAG. the body temperature of animals raise 0.35℃. The body temperature of CG was compared with that of FG an obvious difference (P
ABSTRACT
Sixteen hybrid dogs were randomly divided inio two groups: (1) HSG grouphemorrhagic shock pretreated with ginseng fruit saponin at 30 min before bleeding and(2) HS group, hemorrhagic shock pretreated with same volum of saline. The hemorrhagicshock was induced by bleeding from carotid artery. Mean arterial blood pressure of 5. 3 kPawas maintained for 4 hr. In there 2 group of animals, the survival rates average pressurebefore put to death, end hemorrhage were obviously all different (P
ABSTRACT
Fourty rats were divided into four groups and the aseptic inflammation was induced by subcutaneous injection of cronton oil into the back of 30 rats. Body temperature were gradually rose up after injection. The highest temperature appeared on the second day, then run down in the following days, and went back to normal on the eighth day. Brain were dissected in 10 normal rats without fever(group 1), other 10 rats at the peak of fever(group 2), and another 10 rats in the recovery phase on the third day (group 3). Ten rats in group 4 were used for observing the whole process of temperature change from injection day to the eighth day without brain dissection. The results showed that at the peak of fever, the levels of both cAMP and AC activities in hypo. thalamus were increased (P
ABSTRACT
The fever was induced by intraperitoneal injecting of refined E.Coli endotoxin(ET). The cAMP level and the activity of adenylate cyclase (AC) in differen brain areas of rat were assayed.Both cAMP and AC in hypothalamus were increased significantly at the peak of fever in comparing with the control group (P