ABSTRACT
@#navirus disease 2019 (COVID-19) in the patients younger than 18 years old infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant, and to provide a basis for determining the chest CT changes and efficacy of COVID-19 caused by Omicron virus variant in patients younger than 18 years old. Methods The clinical and imaging data of 30 cases of patients younger than 18 years old infected with COVID-19 Omicron variant, who admitted to the Third People's Hospital of Shenzhen from February 11 to March 26, 2022 were collected and retrospectively analyzed. The clinical manifestations, imaging features and dynamic changes of lesions were summarized. Results A total of 41 intrapulmonary lesions in 30 patients with COVID-19 caused by SARS-CoV-2 Omicron variant. The main manifestations were patchy or nodular ground-glass opacities and/or consolidation, with focal subpleural distribution, lesions mainly occur in the right lung (70.73%, 29/41). There were 42 lesion morphologies, with 22 (52.38%) striped shadows and 16 (38.10%) nodular shadows, with small lamellar and patchy shadows predominating. There were 36 lesion density variations, with ground glass shadows being the most common, with a total of 24 ground glass shadows (66.66%) in each lobe of the lung, and also 6 consolidation lesions (16.67%) and 6 mixed ground glass opacity and consolidation lesions (16.67%). With the progression of the disease, lesions gradually enlarged, appeared on the 2nd day (312.93 mm3), peaked on the 9th day (1 837.18 mm3). The average absorption time of the lesions was (16±3) days, and there was no significant difference between the absorption time of patchy and nodular lesions (ground glass and/or consolidation) (t=0.853, P>0.05). The lesions showed focal ground-glass opacity in the early stage, 77.78% lesions were absorbed after treatment in the late stage. Inflammatory nodules were absorbed slowly (9-19 days), without residual fibrotic changes. Conclusions The imaging manifestations of COVID-19 in patients younger than 18 years old infected with SARS-CoV-2 Omicron variant have certain characteristics, showed patchy or nodular ground glass opacities and/or consolidation, mainly distributed in the subpleural area, with small and few lesions and slow change, didn't remain fibrosis. Being familiar with its clinical and imaging manifestations can assist in early diagnosis, but confirming the diagnosis requires a combination of epidemiological history, clinical symptoms, SARS-CoV-2 nucleic acid and radiological manifestations.
ABSTRACT
@#Abstract: The demand for reliable toxicological data of chemicals runs through every link of occupational health work. The prevention of occupational diseases involves high requirements for the standardization of chemical toxicity assessment in occupational health institutions. Good laboratory practice (GLP) emphasizes the integrity of the test process to trace and supervise the whole process of the test, which is conducive to the standardization of chemical toxicity identification. Therefore, the standardized construction of GLP laboratories is an important starting point for occupational health institutions to carry out chemical toxicity identification. In the construction and management process of GLP laboratories for chemical toxicity identification, occupational health institutions need to build a sound organization and operation system, carry out systematic training and assessment of personnel, establish standard operating norms and emphasize their importance, strengthen the management of facility environment and laboratory, pay attention to quality control and process supervision, and constantly improve their own ability level. To actively adapt to social development and market demand, to provide strong support for occupational health work.
Subject(s)
Adolescent , Adult , Female , Humans , Male , Middle Aged , Young Adult , Coinfection/virology , Respiratory Tract Infections/virology , Acute Disease , China/epidemiologyABSTRACT
Sophora moorcroftiana [Wallich] is an endemic shrub species in Tibet, China, and is a plant with a great value in folk medicine. The previous studies had shown that the ethanolic [95%] extracts were much more effective than other extracts from Sophora moorcroftiana seeds on antiproliferative effects, inducing apoptosis in the human stomach cancer SGC-7901 cell line in vitro. To investigate the antitumor activity of the ethanolic extracts from Sophora moorcroftiana seeds, various doses of ethanolic extracts [200 mg/kg/d, 400 mg/kg/d, 800 mg/Kg/d] were administered via gavage to tumorbearing mice with S180 sarcoma cell for ten days. The weights of tumor tissue stripped from the left flank, TNF-alpha and IL-2 in blood-serum were tested and analyzed for photochemical composition, using standard procedures. The weight of tumor tissue was significantly decreased upon the treatment with ethanol extracts, but the decrease was more prominent in the group receiving ethanol extracts treatment at 800 mg/kg/d [1.35 +/- 0.21mg] and the inhibition rate on the growth of tumor tissue was higher [28.1%]. The structural changes of post-treatment in the tumor tissue by the ethanolic extracts at a dose of 800 mg/kg/d showed larger areas of necrosis and more significantly invaded lymphocytes. IL-2 and TNF-alpha in serum from the treated mice significantly increased in ethanolic extract-treated groups, compared with the untreated control animals. This suggested that the ethanolic extracts from Sophora moorcroftiana seeds had a weak antitumor role and in high concentration to tumor-bearing mice in vivo, the 95% ethanolic extracts was rather effective