ABSTRACT
In recent years, with the in-depth research on intestinal microecology, probiotics, probiotics, synbiotics, fecal bacteria transplantation and other microecological therapies have become new clinical treatment and intervention methods. The occurrence and development of some chronic diseases are closely related to the disorder of intestinal flora. Therefore, in clinical practice, the treatment and adjuvant treatment of chronic dis-eases related to intestinal flora disorder with the method of intestinal microecology will bring better treatment op-tions and clinical prognosis. How to better regulate intestinal flora to bring more benefits to such patients, as well as what kind of microecologics and treatment methods are the primary problems and challenges in the inter-vention of chronic diseases with microecologics. Based on the current trend of intestinal microecological inter-vention in chronic diseases, this article proposedthe microecological intervention strategy, in order to improve theunderstanding of this topic.
ABSTRACT
Innate lymphoid cells are the most recently discovered family of lymphocytes and a group of innate immune cells. They cannot directly participate in specific immune responses due to lack of pattern recognition and recombination receptors. According to the transcription factors that regulate their de-velopment and function and the cytokines that they can produce, ILCs can be divided into three groups:ILC1, ILC2 and ILC3. ILC1 and ILC3 also include several different subtypes. ILCs play an important role in maintaining the integrity of intestinal mucosal epithelium, regulating intestinal microbiote, promoting the de-velopment of the intestinal immune system and regulating intestinal inflammation. This article reviews the roles of ILCs in intestinal homeostasis maintenance and the development of intestinal diseases.