Predictive value of apolipoprotein B to apolipoprotein A-Ⅰ ratio combined with carotid intima media thickness in acute cerebral infarction / 中风与神经疾病杂志

@#To investigate the value of apolipoprotein B to apolipoprotein AⅠ ratio combined with carotid intimamedia thickness in predicting acute cerebral infarction.Methods Patients with acute large artery atherosclerotic cerebral infarction in the anterior circulation who were hospitalized in the Department of Neurology，The First Affiliated Hospital of Xinjiang Medical University from July 2020 to June 2021 were selected as the case group.Patients with noncardiovascular and cerebrovascular diseases who were hospitalized during the same period were randomly selected as the control group.The clinical data and laboratory results of the two groups were compared，and the risk factors of acute cerebral infarction were analyzed.To explore the predictive value of apolipoprotein B to apolipoprotein AⅠratio combined with carotid intimamedia thickness in the incidence of cerebral infarction.The clinical data and laboratory results of the two groups were compared.The influencing factors of acute cerebral infarction were analyzed by logistic regression.The receiver operating characteristic curve was used to analyze the predictive value of the ratio of apolipoprotein B to apolipoprotein AⅠcombined with carotid intimamedia thickness in the incidence of cerebral infarction.Results The study included 143 patients with acute cerebral infarction and 122 patients with noncardiovascular and cerebrovascular diseases.Multivariate analysis showed that smoking（OR=3.448，95%CI 1.609-7.391），diabetes（OR=2.884，95%CI 1.389-5.989），carotid intimamedia thickness （OR=1.633，95%CI 1.219-2.189），Leukocytes （OR=1.258，95%CI 1.036-1.527），free fatty acids（OR=14.113，95%CI 1.942-102.558），ratio of apolipoprotein B to apolipoprotein AI（OR=10.896，95%CI 2.290-51.846），D Dimer（OR=4.690，95%CI 2.097-10.488），homocysteine（OR=9.594，95%CI 1.112-82.772） were independent risk factors for large atherosclerotic cerebral infarction.The value of the ratio of apolipoprotein B to apolipoprotein AⅠ [JP3]and carotid intimamedia thickness in predicting acute cerebral infarction was analyzed by receiver operating characteristic curve.The results showed that the area under the curve was 0.757（95%CI 0.699-0.816），the best predictive value was 0.466，the sensitivity was 81.8%，and the specificity was 58.2%.Conclusion The ratio of apolipoprotein B to apolipoprotein AⅠ and the carotid intimamedia thickness are related to the atherosclerotic cerebral infarction of the anterior circulation large arteries，and they have a certain value in jointly predicting the incidence of cerebral infarction.

Study on the relationship between plasma lipoprotein a concentration and acute ischemic stroke in young people in Xinjiang / 中风与神经疾病杂志

@#To investigate the relationship between plasma lipoprotein a concentration and acute ischemic stroke in young people in Xinjiang.Methods 316 young acute ischemic stroke patients who were hospitalized in the Neurology Center of the First Affiliated Hospital of Xinjiang Medical University from July 2016 to December 2020 were selected as the young stroke group，and 637 young nonstroke patients hospitalized during the same period were randomly selected As a youth nonstroke group. The medical history and clinical data of all subjects were collected，and the relationship between plasma lipoprotein a concentration and the occurrence of acute ischemic stroke in young people was analyzed. Results The plasma lipoprotein a concentration in the youth stroke group［140.55 （208.88）］was significantly higher than that in the youth nonstroke group［95.00 （151.38）］.Comparing the plasma lipoprotein a concentration of the young stroke group and the young nonstroke group according to ethnicity，whether it is Han，Uygur or Kazakh，the plasma lipoprotein a concentration of the young stroke group is higher than that of the young non stroke group（P<0.05）. Multivariate logistic regression analysis indicated that lipoprotein a may be one of the independent risk factors for acute ischemic stroke in young people in Xinjiang（OR=1.601，95%CI 1.342～1.910，P<0.05）. Further explore the relationship between the concentration of plasma lipoprotein a and the occurrence of acute ischemic stroke in Han，Uygur，and Kazakh youths. It shows that the increase of lipoprotein a level in Han youth is significantly related to the occurrence of acute ischemic stroke in young people. 1.751 （95%CI 1.404～2.183，P<0.05）；with the increase of plasma lipoprotein a concentration，acute deficiency The risk of bloody stroke also further increased. The risk ratio of the study population at the highest quartile level to the study population at the lowest quartile level was 4.948 （95%CI 2.528～9.686，P<0.05）.However，in the Uygur and Kazakhs，there is no correlation between the concentration of lipoprotein a and the occurrence of acute ischemic stroke in young people.Conclusion The concentration of plasma lipoprotein a is associated with the occurrence of acute ischemic stroke in young people in Xinjiang. Further exploring the ethnic differences in the correlation，it is found that the plasma lipoprotein a concentration is closely related to the occurrence of acute ischemic stroke in the Han youth，and there is no correlation between the Uyghur and Kazakh youths.

Association between short-term outcomes and collateral circulation status in patients with acute ischemic stroke receiving thrombolysis therapy: a systematic review and meta-analysis / 中华全科医师杂志

Objective To evaluate the association between short-term outcomes and collateral circulation status in patients with acute ischemic stroke receiving thrombolysis therapy.Methods Full-text articles published from January 2000 to November 2016 in Cochrane Library,Medline,Embase and Web of Science electronic database were retrieved and their quality was assessed.The association between short-term outcomes and collateral circulation status were analyzed by random-effects models.Results Twenty three studies involving 2 849 patients were included in quantitative synthesis.The results showed that good collateral circulations had a beneficial effect on favorable outcomes at 3 or 6 months (RR =2.26,95％ CI:1.85-2.77,P =0.00),and were also associated with a lower rate of symptomatic intracranial hemorrhage (RR =0.56,95％ CI:0.47-0.67,P ＜ 0.01) and a lower rate of mortality (RR =0.30,95％ CI:0.22-0.40,P ＜ 0.01).Conclusion The baseline collateral cimulation status is associated with the short-term outcomes in patients with acute ischemic stroke receiving thrombolysis therapy.