ABSTRACT
This study was conducted to identify a biomarker for multiple sclerosis [MS] that can be used as a predictor of relapse and disability. Sera of 26 consecutive relapsing-remitting MS [RRMS] patients were screened for switch-associated protein 70 [SWAP-70] antibody, which was previously identified by protein macroarray. The serum levels of several cytokines, chemokines and soluble adhesion molecules related to MS attacks were measured by enzyme-linked immunosorbent assay [ELISA]. A possible correlation was sought among levels of SWAP-70 antibody, measured humoral factors and disability scores. ELISA studies showed high-titre SWAP-70 antibodies in 16 [61.5%] RRMS sera obtained during the attack period and 9 [34.6%] sera obtained during remission. There was a significant inverse correlation between SWAP-70 antibody levels and expanded disability status scale scores, CXCL10, soluble VCAM-1, CXCL13 and soluble VLA-4 levels. Our results showed that SWAP-70 antibodies could potentially be utilized as relapse and prognostic biomarkers in MS. Whether or not SWAP-70 antibodies have any effect on disease mechanisms requires further investigation