ABSTRACT
Tu-Jia medicine is an important part of traditional Chinese medicine (TCM).“San-Yuan doctrine”is the guiding ideology of Tu-Jia medicine, but there is no systematic exposition of its literature origin. This paper ar-gued that“San-Yuan doctrine”of Tu-Jia medicine was originated in the“San-Yuan”of Taoism. Its formation was closely related to the impact of Taoism and Tu-Jia culture, the understanding of human physiology and pathology in Tu-Jia medicine. This paper expounded the origin of“San-Yuan doctrine”, the guiding ideology of Tu-Jia medi-cine and Taoism culture through citing a number of theoretical bases. First of all, the concept of“San-Yuan”in Tu-Jia medicine originated in Taoism. Secondly, legends about the Lord Lao-Zi and Medicine King Bodhisattva in Tu-Jia medicine were closely related with Taoism. Moreover, there existed important links between Tu-Jia medicine and Taoist medicine. For example, both of them are aware of the importance of brain. The reason, I think, is firstly due to the penetration of Taoism in Tu-Jia culture. Taoism culture has a profound influence on Tu-Jia culture. Sec-ondly, the understanding of human physiology and disease in Tu-Jia medicine is closely related to“three”. There-fore, Tu-Jia medicine took“San-Yuan doctrine”as its own guiding ideology. It is of great significance to the study of ethnic minority medicine culture and inheriting its academic thoughts by the study of Tu-Jia medicine origin.
ABSTRACT
This study successfully established in v itro model of Alzheimerˊs disease ( AD ) in order to investigate effects and mechanisms on AD by Bushen-Huatan-Yizhi Recipe (BSHTYZR, replenishing kidney-essence and removing phlegm to benefit wisdom ) . The PC-12 cells affected by Aβ1-42 incubated were produced for neuron cell model of AD . Then , they were intervened by the serum containing BSHTYZR , which were compared to the serum containing indomethacin . The cell morphology was observed . The neuronal survival was assessed by counting MTT assay . The expression of APP mRNA was detected with RT-PCR . And the protective effect of BSHTYZR on neuronal cells and neurotoxic effects of anti-Aβ was observed . The results showed that 2 . 5 mmol/L Aβ1-42 can significantly decrease the cell viability . The RT-PCR was used on semi-quantitative analysis for expression of APPmRNA. It showed that expression of APP mRNA was increased in each group, and the BSHTYZR group can reduce the expression significantly ( P < 0 . 01 ) . It was concluded that the BSHTYZR method can protect nerve cells , suppress the expression of APP mRNA , and reduce the toxic effects .
ABSTRACT
Objective To study the effect of dipsacus on the expression of β-amyloid in parietal cortex and hippocampus of Alzheimer's disease model rats.Methods A total of 40 rats were randomly divided into control group,model group,dipsacus group and vitamin E group (n=10,each)General situation of rats was observed after 42 days of dipsacus treatment.The ability of learning and memory in rats was tested by Morris water maze.The content of β-amyloid in parietal cortex and hippocampus of each group rats were measured using double antibody sandwich method.Results Model group compared with control group showed that general conditions deteriorated markedly;escaping delitescence was prolonged significantly(P＜0.01) ; the activity time on the former platform quadrant reduced significantly (t=4.6261,P=0.0002) ; the number of crossing the former platform reduced significantly (t=6.5335,P=0.0000) ; the content of Aβ in parietal cortex and hippocampus increased significantly (t=4.2812,P=0.0004) (t=5.2499,P=0.0001).Dipsacus group and vitamin E group compared with model group showed that general condition improved significantly;escape latency was shortened significantly (P＜ 0.01); the activity time on the former platform quadrant increased significantly [(45.76±12.15) s,(48.70±10.25) s and (30.20±10.48) s (t=3.0666,3.9908,P=0.0066,0.0009)]; the number of crossing the former platform increased significantly [(3.02±1.19) t/2min,(3.56±0.85) t/2min and (1.43 ± 1.24) t/2min (t=2.9256,4.4804,P=0.0090,0.0003)]; the content of Aβ in parietal cortex and hippocampus reduced significantly in parietal cortex [(280.37-51.40) pg/g,(263.14 ± 45.52) pg/g versus (337.46 ±70.51) pg/g (t=2.1164,2.8003,P=0.0485,0.0118)],in hippocampus [(295.60±67.58)pg/g,(274.38±57.56)pg/g versus (388.26±83.72)pg/g(t=2.9256,4.4804,P=0.0090,0.0003)].Conclusions Dipsacus can reduce expression of Aβ in brain areas related to general intelligence that may have anti-Alzheimer's disease action.The active ingredients of dipsacus may be natural vitamin E.
ABSTRACT
AIM: To observe the clinical effect of Complound Rich Selenium Refined Konjal Meal Capsule on hyperlipemia. METHODS: The patients with hyperlipemia were randomly divided into two groups. The treatment group was given (0.5) g of Compound Rich Selenium Refined Konjai Meal Capsule, twice a day. The control group was given (0.2) g of hexanicotol, three times a day. The course lasted four weeks. The clinical therapy, the effect decreasing of blood lipid and influence on blood lipid of two groups were observed. RESULTS: Compared with the control group, the clinical effect of treatment group is better than the former,(P