ABSTRACT
Objective: The aim of this study was to explore the correlation between the clinicopathological characteristics of colorectal adenocarcinoma and the growth pattern, tumor budding, and CD8+T lymphocyte infiltration in anterior invasive margins, and to assess their value as prognostic indicators. Methods: Paraffin embedded samples were collected from 126 patients with primary colorectal adenocarcinoma who underwent surgical resection in Zhangye People's Hospital Affiliated to Hexi College from January 2008 to December 2019. A total of 126 pathological sections were stained by immunohistochemistry. Anti-cytokeratin antibodies were used to mark tumor cell budding and anti-CD8 antibody markers T lymphocytes were evaluated. Results: In colorectal adenocarcinoma, infiltrative growth patterns and high-grade tumor budding in invasive margins were significantly associated with pathological stage of tumor size (pT) (P=0.029 and P<0.001, respectively), pathological stage of lymph node metastasis (pN) (P<0.001 and P=0.023, respectively) and vessel infiltration (P<0.001 and P<0.001, respectively). Furthermore, high-grade CD8+T lymphocyte infiltration was associated with the absence of lymph node metastases (P=0.050). Conclusions: Infiltrative growth patterns and high-grade tumor budding in colorectal adenocarcinoma invasive margins were correlated with patient prognosis. Importantly, these two features are easily detectable (with the help of pan-cytokeratin immunohistochemistry staining), in a reproducible manner. Therefore, we propose that they could be used as prognostic indicators in colorectal adenocarcinoma patients.
ABSTRACT
Objective Investigation of the Hexi Corridor in Gansu Province in the pathogenesis of esophageal cancer risk factors, prevention and treatment for esophageal cancer provide the basis. Methods Based on the hospital case control study, a survey of the region' s incidence of esophageal cancer risk factors. Results The single factor, multi factors and Logistic regression analysis found that Large quantities of alcohol, eating less fresh vegetables and less meat,eggs and fish, hot drink and diet, family history of esophageal cancer, history of significant mental trauma and low education level factors and esophagus cancer incidence closely related to the incidence of esophageal cancer in the Hexi Corridor is the main risk factors. At the same time, smoking, eating fast, eating sauerkraut was not related to the incidence of esophageal cancer. Conclusion After the investigation discovered this local esophagus cancer morbidity dangerous factor and locality special living conditions factor related, mainly displays in diet aspects and so on habits and customs and energetic factor. These factor function is by no means independent, but is affects mutually, affects mutually forms.