ABSTRACT
Schizophyllum commune is a basidiomycotic fungus that grows ubiquitously on trees and rotting wood. Human infections caused by it are of diverse presentation but are very rare. We present a case of sinusitis caused by S. commune in a 58-year-old female patient with post-COVID-19 infection along with a history of allergic rhinitis and diabetes mellitus type 2. Computed tomography scan findings established the clinical diagnosis of fungal maxillary sinusitis which was confirmed with culture report and polymerase chain reaction followed by sequencing. The patient underwent functional endoscopic sinus surgery. She was treated empirically with itraconazole after surgical excision
ABSTRACT
Introduction: Dengue is a major public health problem in tropical and sub-tropical regions of the world and it is known for serious life threatening complications. Detection of IgM antibodies forms the mainstay for diagnosis of dengue infection. However, IgM antibodies develop after 4-5 days of infection and there is an urgent need for an alternative diagnostic tools that can detect dengue infection earlier. Aim and Objectives: To evaluate the efficacy of NS1 antigen ELISA for early diagnosis of dengue virus infection in a tertiary care hospital Methods-A total of 2106 serum samples from patients with suspected dengue infection were tested for dengue NS1 antigen and IgM anti-body detection by ELISA. Results: 765 (36.32%) were positive for dengue NS1 antigen and 857 (40.69%) were positive for dengue IgM antibody. NS1 antigen was detectable in patient sera from day 1 onwards however; dengue IgM anti-body was detected from day 3 onwards. Out of 765 NS1 antigen positive samples, 562 (73.46%) were positive in acute phase of illness and 203 (26.54%) were positive in convalescent phase of illness. Out of 857 MAC ELISA positive samples, 312 (36.41%) were from acute phase of illness and 545 (63.59%) were from early convalescent phase of illness. Combination of two tests resulted in increase in the positivity rate to 52.66% as against to independent posi-tivity rate of 36.32% of NS1 ELISA and 40.69% of MAC ELISA. Conclusion: Combined use of NS1 antigen assay with MAC ELISA test could significantly improve diagnostic sensitivity of dengue infection
ABSTRACT
Background and Aim: Health care workers accessories like mobile and pen have become important fomites in spread of health care infections and when used at the patient’s point of care may be responsible for cross contamination. Aim is to determine whether mobile phones and pens could play a role in the spread of bacterial pathogens. Methodology: Swabs from from mobile phones and pens were taken and inoculated on blood agar and MacConkey agar plates and the isolates were identified by standard microbiological procedures. Results: 28 /74(37.83%) mobile phone and 22/74(29.73%) pens showed bacterial contamination. Coagulase negative staphylococcus accounted for the majority of positive isolates. Conclusion: Mobiles and pens are potential reservoir for bacteria. They might be a vector in the transmission of potential pathogenic microorganisms. The risk can be reduced by using alcohol-based sanitizing agents for wiping mobile and pen.