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1.
Article | IMSEAR | ID: sea-202591

ABSTRACT

Introduction: Advances in diagnostic radiologic techniqueshas made Fine needle aspiration cytology more specificespecially in hard to access areas like retroperitoneum.Rapid enlargement of tumors occur before clinical signs andsymptoms develop in retroperitoneal area. Present study wasundertaken to study the utility and efficacy of FNAC in earlydiagnosis of neoplastic and nonneoplastic retroperitonealmasses, to study the cytomorphology and diagnostic accuracyof FNAC with respect to tissue diagnosis wherever possible.Material and methods: Study was done in Indira GandhiGovernment Medical College, Nagpur on 70 patients withdiagnosed retroperitoneal masses on radiology either by CTor USG over a period of 2 years. Appropriate staining wasdone and results were compared to histopathology whereveravailable. No major complications occurred during theprocedure or post procedure period. Results were analysed todetermine sensitivity, specificity, diagnostic efficacy of guidedFNAC.Results: Adequate cellular material was obtained in 66cases to study cytomorphology. 46(65.72%) retroperitonealmasses were malignant. 3(4.28%) were benign while 14(20%)were inflammatory. 3 (4.28%)cases were suspicious formalignancy. Cytology was correlated with histopathologicaldiagnosis in all 39 cases where tissue diagnosis was available.Interpretation: No major complications were seen during theprocedure or post FNAC period. Statistical analysis showedsensitivity, specificity and diagnostic accuracy were 100% inthese cases in the present study.Conclusion: FNAC is advantageous in terms of accuracy,rapidity, safety and convenience if done in close cooperationwith radiologist and clinicians. Performed as an OPDprocedure, diagnosis obtained in 24 hours helps to avoidsurgical laparotomy and numerous preoperative investigationsin advanced and inoperable cases and inflammatory lesions.

2.
Indian J Pathol Microbiol ; 2007 Jan; 50(1): 25-7
Article in English | IMSEAR | ID: sea-73088

ABSTRACT

Tonsillar sarcoidosis can be seen as a part of generalized sarcoidosis or in isolation. Typical non-caseating granulomas are seen in the biopsy. We present a case of isolated tonsillar sarcoidosis masquerading as chronic tonsillitis in a young female.


Subject(s)
Adolescent , Biopsy , Diagnosis, Differential , Female , Histocytochemistry , Humans , Palatine Tonsil/pathology , Sarcoidosis/diagnosis , Tonsillitis/diagnosis
3.
Indian J Pathol Microbiol ; 2005 Apr; 48(2): 230-5
Article in English | IMSEAR | ID: sea-75412

ABSTRACT

Renal oncocytomas are rare renal parenchymal neoplasms which have a good prognosis. An accurate pre-operative diagnosis by guided fine needle aspiration cytology helps to plan a more conservative surgery. Cytologic findings in a case of renal oncocytoma are presented. Smears showed polygonal or rounded cells in groups and acinar pattern having a well-defined, granular, eosinophilic cytoplasm, and round regular nuclei displaying very little pleomorphism. Intra and extracellular hyaline material staining pink with May Grunwald Giemsa stain were seen. The resected specimen showed the characteristic findings of oncocytoma. Renal oncocytoma has to be distinguished from granular renal cell carcinoma (RCC) and chromophobe cell carcinoma, because of the markedly different prognosis.


Subject(s)
Adenoma, Oxyphilic/diagnosis , Adult , Biopsy, Needle , Diagnosis, Differential , Female , Humans , Kidney Neoplasms/diagnosis
4.
Indian J Pathol Microbiol ; 2004 Oct; 47(4): 511-5
Article in English | IMSEAR | ID: sea-72653

ABSTRACT

Mammary hamartoma is best viewed as a "breast within a breast" and is most often mistaken for fibroadenoma, phyllodes tumour or lipoma. It shows an abnormal blending of normal breast tissue components and is cured by removal. We present two cases of mammary hamartoma one occurring in a male breast. Although it is true, that all diseases occurring in female breast can also be seen in a male breast, there has been no report of this condition in a male. To the best of our knowledge, this is the first case of mammary hamartoma occurring in a male.


Subject(s)
Adolescent , Adult , Breast Diseases/diagnosis , Breast Neoplasms/diagnosis , Breast Neoplasms, Male/diagnosis , Diagnosis, Differential , Female , Fibroadenoma/diagnosis , Fibrocystic Breast Disease/diagnosis , Hamartoma/diagnosis , Humans , Male
5.
Indian J Pathol Microbiol ; 2003 Jul; 46(3): 437-40
Article in English | IMSEAR | ID: sea-75800

ABSTRACT

Pneumatosis cystoides intestinalis is an uncommon condition characterized by gas filled cysts within the bowel wall. We present a case of a 40-year old male who complained of abdominal pain and distension. The clinical diagnosis was intestinal obstruction and intraoperative impression was intestinal lymphangioma. The resected segment of the bowel showed multiple thin walled, tense, air-filled cysts on the serosal surface, which collapsed with a popping sound when pricked. The histologic diagnosis was pneumatosis cystoides intestinalis. Pneumatosis cystoides intestinalis has varied clinical manifestations, course and outcome depending on its benign or fulminant form. There are varying theories regarding its pathogenesis and it is seen in association with a variety of diseases. Hence it should be interpreted with relevance to its entire clinical context, as it may not be a disease in itself but a sequel to other conditions.


Subject(s)
Adult , Humans , Male , Models, Biological , Pneumatosis Cystoides Intestinalis/diagnosis
6.
Indian J Pathol Microbiol ; 2003 Jul; 46(3): 440-2
Article in English | IMSEAR | ID: sea-73270

ABSTRACT

Benign stromal fragments or extracellular matrix can be seen in aspirates of invasive carcinomas. Although well documented on histology, this feature is rarely observed on fine needle aspirates and can create diagnostic difficulties on smears. Only three such cases have been reported so far. We report two more cases where stromal fragments were seen in association with invasive squamous cell carcinoma (SCC). Two cases of biopsy proved invasive SCC of the cheek and of the larynx presented with metastases to the submandibular salivary gland and to the cervical lymph node respectively. Aspirates of the metastatic sites showed two components: one of SCC and the other benign stroma, both in close approximation with one another. Both patients were treated with radiotherapy. Biopsy of the metastatic sites was not done. Benign stromal fragments can be encountered in aspirates of invasive carcinoma. These may be cellular or myxoid. Since such stromal fragments can also be seen in salivary tumours, adnexal tumours, fibroadenoma and phylloides tumour, their presence should be interpreted in the light of clinical findings of the patient, so that an erroneous diagnosis can be avoided.


Subject(s)
Adult , Biopsy, Fine-Needle , Carcinoma, Squamous Cell/diagnosis , Humans , Laryngeal Neoplasms , Lymphatic Metastasis/diagnosis , Male , Middle Aged , Stromal Cells/pathology , Submandibular Gland Neoplasms/diagnosis
7.
Indian J Pathol Microbiol ; 2003 Jul; 46(3): 385-9
Article in English | IMSEAR | ID: sea-74564

ABSTRACT

A prospective study of 50 cases of treated breast cancer was undertaken to evaluate the status of the contralateral breast by combined physical examination, mammographic screening and mammographically directed FNAB (triple approach method). This study was done to assess the frequency of synchronous (cancers that were simultaneously diagnosed with a tumour in ipsilateral breast) or metachronous (those that occurred in contralateral breast subsequent to first cancer and not detected at the time of treatment of first cancer) malignancy and/or presence of preneoplastic lesions in the contralateral breast. Six percent cases had palpable lump in contralateral breast (synchronous or metachronous), 10% of the cases showed mammographic abnormalities. Mammographically directed FNAB showed atypical/suspicious smears in 8% cases and malignancy in 2% cases, of which infiltrating duct carcinoma was the most frequent. In high-risk group patients triple approach method proved to be extremely important screening procedure for early detection of abnormalities in contralateral breast and helps in significantly reducing the morbidity and mortality associated with it.


Subject(s)
Adult , Biopsy, Fine-Needle , Breast Neoplasms/diagnosis , Carcinoma, Ductal, Breast/diagnosis , Female , Humans , Mammography , Neoplasms, Second Primary/diagnosis , Prospective Studies
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