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3.
Indian J Physiol Pharmacol ; 1975 Jul-Sep; 19(3): 129-34
Article in English | IMSEAR | ID: sea-108431

ABSTRACT

In doses (from 100 mug to 1 mg) nicotinic acid produced positive inotropic and chronotropic action on isolated frog heart. This effect was blocked by pronethalol and guanethidine administration. This effect was not observed in reserpinised frogs. Repeated administration of the same dose of nicotinic acid caused development of tachyphylaxis, in frog's heart preparation. The observations indicate that nicotinic acid induced a release of noradrenaline in frog's heart. On other preparations, such as isolated rabbit heart, rabbit's intestine and guinea pig seminal vesicles, nicotinic acid produced a nonspecific direct depressant action.


Subject(s)
Animals , Anura , Dose-Response Relationship, Drug , Guinea Pigs , Heart/drug effects , Heart Rate/drug effects , Ileum/drug effects , Male , Muscle, Smooth/drug effects , Myocardial Contraction/drug effects , Myocardium/metabolism , Nicotinic Acids/administration & dosage , Norepinephrine/metabolism , Rabbits , Seminal Vesicles/drug effects
18.
Indian J Physiol Pharmacol ; 1965 Oct; 9(4): 163-5
Article in English | IMSEAR | ID: sea-107960
19.
Indian J Med Sci ; 1964 Jan; 18(): 30-4
Article in English | IMSEAR | ID: sea-66683
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