ABSTRACT
Background: The Indonesian people were used the leaves of silk cotton tree (Gossypium arboreum L.) and cotton tree (Ceiba pentandra Gaertn.) as an antipyretic, empirically. There is no scientific evidences on the antipyretic activity of these plants. Objective: The aim of this study is to determine the better antipyretic activity of the leaves extract of G. arboreum and C. pentandra in Swiss mice as an animal model. Methods: The steps of the study consisted of extraction, phytochemical screening, and antipyretic activity assay on Swiss mice which induced by 20% yeast suspension. Results: The results showed that the leaves extract of G. arboreum and C. pentandra have antipyretic activity. The effective dose of antipyretic activity for the leaves extract of G. arboreum and C. pentandra is 1120 mg/kg and 189 mg/kg, respectively. Conclusion: The antipyretic activity of C. pentandra leaves extract better than G. arboreum leaves.