ABSTRACT
ObjectiveTo investigate the effect of different levels of physical activity on the risk of Parkinson's disease (PD). MethodsA total of 9 726 subjects from 2018 China Health and Retirement Longitudinal Study (CHARLS) data were analyzed with multivariate Logistic regression analysis. ResultsOf the 9 726 subjects, 188 suffered from PD, with a prevalence of 1.93%. The subjects who aged more than 65 (OR = 2.58, 95%CI 1.74 to 3.96, P < 0.001) and widowed (OR = 1.42, 95%CI 1.01 to 1.99, P = 0.043) were at a higher risk of developing PD. Subjects who engaged in high-intensity physical activities (OR = 0.38, 95%CI 0.27 to 0.54, P < 0.001) were at a lower risk of PD. After adjusting for age and marital status, high-intensity physical activity still reduced the risk of PD (OR = 0.42, 95%CI 0.29 to 0.61, P < 0.001). ConclusionHigh-intensity physical activity (over 3 000 metabolic equivalents a week) may reduce the risk of PD.