ABSTRACT
Dengue is a human disease wich may be fatal in its hemorrhagic form. How dengue virus and hostspecified factors underlie virulence and pathogenesis is poorly undrestood. An inmunological disorder is thougth to be involved in dengue physilogical symptoms. Whether the immune response is deleterious or beneficial to the host remains a matther of debate. In this review, we summarized developments in research on viral pathogenesis in the context of apoptosis triggered by dengue virus infection. Apoptosis, an active process of cell destruction, is one of the importand consequences of dengue virus infection in vitro and in vivo. Dengue virus replication induces apoptosis in mouse neurons and human hepatocytes. The ability to activate this genetically programmed cell death pathway is dependent on both viral and cellular determinants
Subject(s)
Humans , Male , Female , Mice , Apoptosis , Dengue/genetics , Dengue/pathology , VirologyABSTRACT
The determination of amino acid changes in the envelop protein by direct sequencing of either genomic RNA or PCR-amplified cDNA fragments provides useful informations for assessing the genetic variability and the geographic distribution of the actually most widespread dengue-2 serotype. The possible link of variations in the envelope protein-gene and virus virulence is discussed