Peripheral Precocious Puberty Caused by Human Chorionic Gonadotropin Producing Pineal Gland Tumor

Background: Pineal gland lesions usually present with central precocious puberty.Case characteristics: A 3½-yr-old boy presented with precocious puberty. Clinically andbiochemically, it was gonadotropin releasing hormone (GnRH) independent. Serum andCSF beta-hCG levels were increased. Thin section magnetic resonance imaging of brainrevealed a pineal gland tumor. Outcome: He received chemotherapy followed byradiotherapy and responded well. Message: CSF ?-hCG should be measured in all cases ofperipheral precocity, and if CSF beta-hCG is elevated, thin section magnetic resonanceimaging of brain should be considered.

retrospective analysis of 334 cases of hemoptysis treated by bronchial artery embolization

To analyze the safety and efficacy of bronchial artery embolization [BAE] in the management of hemoptysis. We conducted a retrospective study of 334 patients who had undergone BAE for hemoptysis from January 2007 to July 2013. Our study included 255 [76.3%] males and 79 [23.7%] females with an age range from five to 81 years old. All relevant arteries were evaluated but only those arteries that showed hypertrophy and significant blush were targeted. Polyvinyl alcohol [PVA] was used in all patients and gel foam was used in combination with PVA where there was significant shunting. Mild hemoptysis was seen in 70 patients, moderate in 195 patients, and severe in 69 patients. On imaging, right side disease was seen in 101 patients, left side involvement in 59 patients, and bilateral involvement in 174 patients. Post-tubercular changes were the predominant pathology seen in 248 patients. Among 334 patients [386 procedures], 42 patients underwent the procedure twice and five patients underwent the procedure thrice. A total of 485 arteries were attempted of which 440 arteries were successfully embolized. Right intercosto-bronchial was the most common culprit artery present in 157 patients, followed by common bronchial [n=97], left bronchial [n=55], and right bronchial [n=45]. We embolized a maximum of four arteries in one session. Immediate complications such as dissection and rupture occurred in only nine sessions [2.3%]. Twenty-five procedures [6.5%] were repeated within two months, which were due to technical or clinical failure and 27 procedures [7%] were repeated after two months. BAE is a safe and effective procedure with a negligible complication rate. Our approach of targeting hypertrophied arteries was effective