ABSTRACT
Wistar strain albino rats were hysterectomized and the estrous cycle was compared with sham operated controls. Duration of estrous cycle in hysterectomized rats increased markedly with significant delay in the luteal phase and this was correlated to the inhibited follicular development of ovary. When these rats were treated with PGF2 alpha and PMSG and subjected to physical exercises, the estrous cycle was synchronised and the ovaries of such animals had active follicular development. Thus the deranged operation of sexual cycle in hysterectomized rats was regulated through physical exercises.
Subject(s)
Animals , Dinoprost/pharmacology , Estrus/drug effects , Female , Gonadotropins, Equine/pharmacology , Hysterectomy , Ovarian Follicle/drug effects , Physical Exertion/physiology , Rats , Rats, WistarABSTRACT
The in vitro studies on the effect of hypophysial gonadotropins (PRL, FSH, LH) on the maturation events of accessory sex organs in prepuberal male rats revealed that prolactin (PRL) alone has both direct as well as androgen mediated effect on the maturation activities. The effect of PRL is age dependent and it had higher activation on the gland system than the duct system.
Subject(s)
Aging/physiology , Animals , Genitalia, Male/drug effects , Male , Prolactin/pharmacology , Rats , Rats, Inbred StrainsABSTRACT
Hypoprolactinemia inhibited epididymal energy metabolism and steroidogenesis and retarded growth of epididymal structure. Hyperprolactinemia promoted the above parameters. Bromocriptine had no direct effect on epididymis, while prolactin directly influenced the tissue metabolism. The epididymal maturation seems to be dependent on the circulating levels of prolactin.