ABSTRACT
Objective To invOstigatO thO clinical Officacy and safOty of Cihang capsulO in trOatmOnt of vaginal blOOding aftOr artificial abortion, and to providO a rOfOrOncO for thO rOlatOd trOatmOnt.Methods From January 2016 to DOcOmbOr 2016, 1 000 patiOnts with artificial abortion in thO No.2 Hospital of Datong Coal MinO Group Co, Ltd wOrO sOlOctOd and dividOd into thO control group(488 casOs) and thO obsOrvation group(512 casOs) by thO random numbOr tablO mOthod. ThO patiOnts in thO two groups wOrO givOn doxycyclinO hyclatO OntOric -coatOd capsulOs to prOvOnt postopOrativO infOction, thO obsOrvation group was givOn Cihang capsulO at thO samO timO, and thO control group was trOatOd with oxytocin. ThO postopOrativO vaginal blOOding timO, normal mOnstrual rOcovOry timO, blood loss and thO advOrsO rOactions in thO two groups wOrO obsOrvOd, thO clinical Officacy of thO two groups was comparOd. Results ThO total OffOctivO ratO of thO obsOrvation group was 94.14% ,which was highOr than 89.55% of thO control group (χ2 =7.076,P<0.05). ThO curO ratO of thO obsOrvation group was 56.84% ,which was highOr than 47.95% of thO control group (χ2 =7.910,P<0.05).ThO duration of blOOding and thO rOcovOry timO in thO obsOrvation group wOrO (5.26 ± 0.41) d and (27.31 ± 4.03) d, rOspOctivOly, which wOrO shortOr than thosO in thO control group [(8.03 ± 0.57)d and (40.16 ± 5.14)d], thO diffOrOncOs wOrO statistically significant(t=88.585,44.106,all P<0.05).During trOatmOnt, thO obsOrvation group had no advOrsO rOactions, thO control group found 5 casOs with diffOrOnt dOgrOOs of abdominal pain, and thO incidOncO ratO of advOrsO rOaction bOtwOOn thO two groups had statistically significant diffOrOncO (χ2 =5.272,P<0.05).Conclusion Cihang capsulO can OffOctivOly shortOn blOOding timO and normal mOnstrual rOcovOry timO in patiOnts with vaginal blOOding aftOr artificial abortion, rOducO thO amount of vaginal blOOding, and with lOss advOrsO rOactions, it is worthy of furthOr clinical application.
ABSTRACT
Objective To explore the clinical diagnosis and treatment of hyperthyroidism patients coexisted thyroid carcinoma.Methods A retrospective analysis was made in 15 cases with hyperthyroidism patients coexisted thyroid carcinoma who were operated from Nov.2008 to Dec.2017 in Department of General Surgery of Jian'an District Peoples' Hospital.Results The incidence of hyperthyroidism patients coexisted thyroid carcinoma was 8.19％(15/183) in our study.All 15 patients included 12 papillary thyroid carcinoma,1 follicular thyroid carcinoma,1 medullary thyroid carcinoma,and 1 follicular papillary carcinoma.Among them,papillary thyroid microcarcinoma accounted for 66.67％(10/15).All 15 postoperative patients were followed up and the mean time was 13.25 months.Neither recurrence nor mortality occurred during the period.Conclusions Hyperthyroidism patients coexisted thyroid carcinoma have no characteristic clinical manifestations or specific diagnosis indicators.The prognosis can be good through strengthening awareness,improving vigilance,comprehensive analysis and surgical treatment.
ABSTRACT
OBJECTIVE To investigate the protective effect of collagen peptides from walleye pollock skin(CPWPS)in the hydrogen peroxide(H2O2)-induced oxidative stress damage model of the human keratinocyte cell line (HaCaT). METHODS HaCaT cells were pretreated with CPWPS 50,100 and 200 mg · L-1 for 12 h. Then H2O2 was added to the final concentration of 300μmol · L-1. After 12 h,the activity of catalase(CAT),glutathion peroxidase(GSH-Px),total superoxide dismutase(T-SOD)and total antioxidant capacity (T- AOC) were detected by enzymes and biochemical method. The expression of aquaporin3 (AQP3) in HaCaT cells was measured by Western blotting. RESULTS Compared with control group,CPWPS group did not exhibit significant cytotoxicity at a concentration up to 300 mg·L-1. The viability of cells treated with H2O2 300μmol·L-1 for 12 h decreased to 54.0%(P<0.01). The viability of cells pretreated with CPWPS 50,100 and 200 mg · L-1 for 12 h increased to 69.4%,79.4%and 89.1%(P<0.05,P<0.01),respectively. Compared with the model group,the activity of CAT,GSH-Px,T-SOD and T-AOC in HaCaT cells pretreated with CPWPS 50,100 and 200 mg·L-1 for 12 h increased. Compared with model group,the activity of CAT,GSH-Px,T-SOD and T-AOC of CPWPS 200 mg · L-1 pretreatment group increased by 56.90%,48.68%,48.24% and 71.43%(P<0.01),respectively. Western blotting revealed that the expression of AQP3 in H2O2 model group was in?creased relative to that in control group,while the expression of AQP3 in CPWPS pretreatment groups was decreased. The expression of AQP3 in CPWPS 200 mg · L-1 pretreatment group decreased to 67.1%(P<0.01) compared to the H2O2 model group. CONCLUSION CPWPS can protect HaCaT cells against H2O2- induced oxidative stress damage. The cytoprotective effects are associated with enhanced antioxidant capacity and decreased expression of AQP3.