ABSTRACT
Objective:To investigate the effect and related mechanism of quetiapine fumarate tablets combined with valproate sodium tablets in the treatment of depression, and its influence on quality of life.Methods:From January 2017 to January 2019, 96 patients with depression admitted to the Second People's Hospital of Lishui were divided into control group ( n=48) and observation group ( n=48) according to the random digital table method.The patients in the observation group were treated with quetiapine fumarate tablets combined with sodium valproate tablets, while the patients in the control group were treated with sodium valproate.Both two groups were treated for 8 weeks.The therapeutic efficacy, Pittsburgh Sleep Quality Index (PSQI), Hamilton Depression Scale (HAMD), 5-HT, substance P (SP), neuropeptide Y (NPY) and World Health Organization Quality of Life Scale (WHOQOL-BREEF) were compared before and after treatment. Results:The total effective rate of the observation group (91.67%) was higher than that of the control group (70.83%) (χ 2=6.838, P<0.05). After treatment, the scores of PSQI and HAMD in the observation group[(8.74±1.29)points and (14.35±1.37)points] were lower than those in the control group [(10.85±1.43)points and (21.19±2.09)points] ( t=7.591, 18.963, all P<0.05). After treatment, the serum levels of 5-HT [(43.17±7.46)μg/L] and NPY [(7.98±0.43)mg/L] in the observation group were higher than those in the control group [(34.36±5.18)μg/L and (6.59±0.37)mg/L], while the SP level [(3.98±0.54)mg/L] in the observation group was lower than that in the control group [(5.43±0.67)mg/L], the differences were statistically significant( t=6.721, 16.976, 11.674, all P<0.05). After treatment, the scores of environmental field [(65.78±2.63)points], social relationship[(60.31±3.25)points], psychology[(71.83±3.15)points] and physiology [(69.83±3.56)points] in the observation group were higher than those in the control group [(58.91±2.35)points, (54.73±2.32)points, (64.36±2.78)points, (61.15±2.89)points]( t=13.495, 9.682, 12.319, 13.115, all P<0.05). There was no statistically significant difference in adverse reactions between the two groups ( P>0.05). Conclusion:Quetiapine fumarate tablets combined with sodium valproate tablets is effective in the treatment of depression, which can increase serum 5-HT and NPY levels and decrease SP level, and improve the quality of life of patients.