ABSTRACT
Background: There has been an alarming rise in the incidence of various diseases including that of cancer in the world with increase in the incidence of cutaneous malignancies owing to various changes that have taken place in the society over the past few years with respect to the culture, the lifestyle and also a contributory role has been played by the changes in the atmosphere as a result of increase in the air pollutants in the environment. Based on the scenario, we decided to conduct a study to evaluate the presentation and the management cutaneous malignancies in a teaching hospital set up in central india.Methods: A retrospective study was conducted between the time period of 1 year on the records of patients who were diagnosed with cutaneous and related malignancies who were treated at our Institute on a predesigned semi structured performa. SPSS version 23.0 was used for the analysis of the data collected.Results: We evaluated a total of 29 cases, Squamous cell carcinoma (SCC) was the most common histological type (51.72%) followed by melanoma (27.59%) and basal cell carcinoma (BCC, 20.69%). 75.86% of patients with cutaneous malignancies were males and 24.14% were females. Mortality rate observed was 13.7%.Conclusions: The most common cutaneous malignancy seen in this study was squamous cell carcinoma having increased propensity towards males than females. Rate of loco-regional disease and median disease-free survival is directly dependent on the adequacy of disease-free surgical margin and to the limited extent on the adjuvant therapy.
ABSTRACT
Background: C-reactive protein (CRP) is a valuable biomarker of sepsis. Levels of CRP increase very rapidly in response to infection, and decrease just as rapidly with the resolution of the condition. The aim of the research was to study, C-reactive protein levels in patients of sepsis and to study the pattern of CRP levels in patients of Sepsis with hypertension, diabetes, smokers and alcoholics.Methods: This prospective observational cohort study was conducted from December 2016 to September 2018 in 100 cases of sepsis. Patients presenting in emergency with sepsis were included as subjects. C- reactive protein was measured in every patient at the time of admission and after 72 hours. Facts related to history, clinical examination and biochemical parameters were recorded in a pretyped proforma. Data were analyzed using SPSS software.Results: Males outnumbered females. Most of the patients40(40%) were in the age group of less than 30 years age group. CRP levels were markedly elevated in patients with diabetes mellitus (92.2±102.63) as compared to patients with hypertension (36.66±26.97) or both (24.20±12.87). CRP levels were higher in alcoholics (60.59±44.20) as compared to smokers (13.37±10.96). CRP levels decreased significantly after 72 hours compared to CRP levels at the time of admission (p <0.001) across all patients suggestive of acute infection.Conclusions: Serial CRP measurement, rather than a single determination at the time of admission, is cheap and valuable in the diagnosis of sepsis and in monitoring the response to therapy. CRP levels shows exaggerated response in diabetes mellitus and alcoholics with sepsis in this study.