ABSTRACT
Autism is most common mental disabilities in childhood with unknown aetiology nowadays. In our Siddha paediatric text, the symptoms of Mantha sanni are nearly correlated with Autism Spectrum Disorder (ASD). Objectives: The Main objectives of the study is to evaluate the Siddha therapeutic management and to analyse the clinical assessment of Mantha sanni (Autism Spectrum Disorder) with Experimental formulations and procedures and the secondary objectives are to calibrate the resemblance and the equivalence of Mantha Sanni with Autism Spectrum Disorder and to explore the Siddha therapeutic management in Autism children. Methods: In preclinical studies of Physicochemical, Phytochemical activities and Pharmacological activities were done. In clinical studies, among 30 children were included in inclusion criteria and received Kuruver kudineer as internal twice a day and Sambrani thuvalai and Mysatchi pugai as external once in a day. The Experimental period was 90 days and the activities of ASD children were recorded 0th day followed by every 30th day. Results and Discussion: In this clinical study indicating that both internal and external medicine had superior action as far as improvement in ASD is considered. Since Kuruver Kudineer use is to enhance cognitive skills, enhance nerve impulse transmission, research has been focused on the mechanism behind this activity. Thuvalai with Sambrani ennai use to enhance the Sitting tolerance, invigorating feeling and can give comfort. Fumigation with Mysatchi pugai is one of the methods of treatment in ancient period. It has to enhancing the mind calming activity, reduced hyperactivity, induced sound sleep, reduced screaming and irritable cry. In Statistical analysis, there is significant difference between before and after treatment on clinical assessment parameter score i.e. 86% improvement in this score after treatment. Based on the results of this clinical study, it can be conclude that Kuruver kudineer as internal and Sambrani thuvalai and Mysatchi pugai as external. It has a definite action as well as clinical efficacy on symptoms in ASD children seen in regular OPD and IPD. The effects of Internal and external therapies may be due individual drugs multipronged action. Further study is required for scientific validation to prove its clinical efficacy in multicentre clinical study.
ABSTRACT
Mantha Sanni (Autism) is a Mukkuttra disease that is imbalance of all the three main fundamental principles of Vatham, Pitham and Kabam. Mantha Sanni is a neuro developmental disorder typically appearing in the first one and half years of life and characterised by impaired social and communication skills.. In the all over the world, the surveillance study identified 1 in 68 children suffering with ASD. In India, the prevalence ratio is 1:46. It is about 4.5 times more common among boys (1:48) than among girls (1:189). The higher prevalence rate was observed in the rural area. Socioeconomic status may be one of the fundamental indicators for ASD in India. Autism spectrum disorder is the world most common disorder in Children. In this study, I have to present 3 case reports of ASD children based on the assessment scale. The main course of treatment are Brami Nei as internal and Varmam as External therapy in the recommended dose as per Siddha pharmacopeia for 3 months. After 3 months, ASD children improve the cognitive skills and eye to eye contact Hyperactivity reduced well. Most of the formulation acting on psyche is ghee based. It is well established that the drugs to have its action on brain should have the capacity to cross the blood brain barrier and for the purpose ghee based Brahmi Nei is recommended for ASD in children. Manipulative therapy like Varma is to enhance the mind calming activity with sound sleep, good eye to eye contact and to reduce anxiety, hyperactivity. All the ingredients in both Internal medicines are herbal. So my attorney has to conclude the Siddha management therapy might be good and safest. It will be definitely efficacy in treating ASD children. Hence, Brami Nei as internal Varmam as External therapy may have a role to curing the ASD children.