ABSTRACT
The hormonal and physiological changes that come with pregnancy are unique. The aim of this clinical investigation was to observe a correlation between dental pulpal pain and hormonal changes during pregnancy. Methods: Out of hundred pregnant females examined seventy four females were having tooth or teeth indicative of either pulpal therapy or root canal treatment (RCT). On explaining their dental status forty pregnant females with no pain or mild pain agreed to take dental treatment, they were grouped as Group A and the remaining thirty-four who were reluctant and refused dental treatment were classified in Group B. Results: In Group A, thirty-five pregnant got their dental treatment completed along with regular Obstetrics & Gynecological (Obs&Gyne) follow up. In Group B, twenty- four pregnant females were on regular Obstetric & Gynecological follow up and ten of them even did not turned up for either. In Group B twentytwo pregnant females turned back to seek dental treatment due to pain, inflammation or inability to chew food during third trimester which were pain free earlier. In Group A, three out of five also came back for dental treatment. All the data collected was subjected to statistical analysis using paired-t test and Pearson r correlation test. Conclusion: Significant difference was observed with reduced pain threshold during third trimester and +1 coefficient was found stating a significant relationship between dental pulpal pain and raised levels of estrogen and progesterone during pregnancy.
ABSTRACT
Background: Experimentation confirmed the conclusion that bone allografts, like other tissue and organ allografts, are immunogenic. These immune responses cause resorption of allograft, thus lowering the bone formation capacity of the graft. An attempt has been made in this study to prevent immune reactions and achieve enhanced regeneration of allograft-demineralized freeze-dried bone matrix by incorporating it with an immunosuppressive drug Cyclosporine-A (CsA) in the treatment of human periodontal infrabony defects. Materials and Methods: Fifteen patients showing clinical evidence of almost bilateral infrabony defects requiring bone grafting procedures were selected. In each patient, the infrabony defect of one side of the arch was designated as Group A (control site) and the infrabony defect of the contralateral side of the same arch was designated as Group B (test site). Results: On comparative evaluation of the two groups (by Student t-test), the mean values of reduction in probing depth (P=0.81 NS ) and gain in clinical attachment level (P=1.00 NS ) of Group B were found to be greater than that of Group-A, but the differences were statistically non-significant. The mean linear bone fill (P=0.010 ** ) of Group B was also detected to be higher than that of Group A, and the difference was found to be statistically significant. Conclusion: Increase in linear bone fill in Group B signifies the role of CsA in augmenting the regenerative potential of allograft by eliminating immune reactions.