ABSTRACT
[Abstract] Objective To evaluate the clinical value of echocardiography and blood lipid level in the diagnosis of coronary heart disease (CAD). Methods A retrospective analysis was conducted on 240 suspected CAD in-patients who were treated in the Second Hospital of Nanjing, Southeast University from Jun. 2013 to Oct. 2014. The patients were divided into non-CAD group (n＝58) and CAD group (n＝182) according to the results of coronary angiography. The patients in CAD group were further divided into single vessel lesion group (n＝84) and multi-vessel lesion group (n＝98). The indexes of color Doppler echocardiography and blood lipid levels were compared between non-CAD group and CAD group, and single vessel disease subgroup and multiple vessel disease subgroup. Logistic regression was used to analyze the influencing factors of CAD. Results E-peak velocity (E) in early diastolic phase and the ratio of E peak velocity to late diastolic phase A-peak velocity (E/A) in CAD group were lower than those in non-CAD group; the E-peak deceleration time (DT) and left ventricular isovolumetric relaxation time (IVRT) were longer than those in non-CAD group; the left atrial diameter (LAD), interventricular septal thickness (IVS) and left ventricular posterior wall thickness (LVPW) were higher than those in non-CAD group; and the left ventricular diameter (LVD) was larger than that of non-CAD group (all P0.05). In patients with CAD, E in multi-vessel lesion subgroup was higher than that in single vessel lesion subgroup; E/A in multi-vessel lesion subgroup was lower than that in single vessel lesion subgroup; DT and IVRT were longer than those in single vessel lesion subgroup; and LAD, IVS, LVPW and LVD were larger than those in single vessel lesion subgroup (P0.05). The levels of serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) in CAD group were higher than those in non-CAD group, and the level of high-density lipoprotein cholesterol (HDL-C) was lower than that in non-CAD group (all P0.05). The levels of serum TC, TG and LDL-C in multi-vessel lesion subgroup were higher than those in single vessel lesion subgroup, and the HDL-C level was lower than that in single vessel lesion subgroup (all P0.05). Logistic regression analysis showed that age, TC, IVRT, LAD and LDL-C were independent risk factors for CAD (all P0.05), and E and HDL-C were independent protective factors for CAD (both P0.05). Conclusion Abnormal blood lipid and left ventricular diastolic function are closely related to the development and progression of CAD, and their abnormalities are of great significance for the clinical diagnosis of CAD.