Benign on cytology, malignant on histopathology: Coexistence of Hashimoto’s thyroiditis with Papillary carcinoma of thyroid.

Papillary thyroid carcinoma (PTC) and Hashimoto’s thyroiditis (HT) are common diseases in clinical practice. Hashimoto’s thyroiditis is the most common autoimmune thyroid disease and the most common cause of hypothyroidism. It is characterized by diffuse lymphocyte infiltration, fibrosis, and parenchymal atrophy. Papillary thyroid carcinoma is the most common malignant neoplasm of the thyroid. There is a high prevalence of association between HT and PTC FNAB is useful for diagnosing PTC in patients with HT associated thyroid lesions. The presence of HT in patients with PTC was associated with disease presentation at an earlier stage, less aggressive clinical course and better outcome. Here we have presented a case of hashimoto's thyroiditis with papillary thyroid carcinoma in a 37 years old female who came with complaints of swelling in front of neck. Cytology and radiology showed features of HT but, on histopathology it was diagnosed as HT with PTC.

Lactating adenoma of the breast: A case report.

Lactating adenomas are rare benign tumors of breast, frequently associated with pregnency and lactation. They are common in the third trimester of pregnancy during second and third decade. They present similarly as other benign lesions of breast and differentiation from them preoperatively is difficult both clinically and radiologically. it is characterised by typical changes of secretory epithelium leading to formation of a well-diffrentiated benign tumor. Cytology and histopathology remains the definitive tests for confirming the diagnosis. Surgery is the treatment of choice. They tend to regress spontaneously and prognosis is generally good. Here we have presennted such a rare case of lactating adenoma arising from 28 years old lactating women.

Incidentally detected carcinoma in situ in a fibroadenoma of breast in a postmenopausal woman: A case report.

Fibroadenomas are the most common benign tumor of the breast. it can occur in women of any age but the peak incidence seen in young adolescent women during the second and third decades of life, Fibroadenoma is a biphasic tumor, composed of an epithelial and a stromal component. Even though they are solitary lesions, multiple fibroadenomas can also occur especially in the older age group. Breast fibroadenomas seemed to display a wide spectrum of proliferative and non-proliferative histologic changes. Of all these changes, carcinoma arising from fibroadenoma is a rare occurrence. Here, we have presented such a rare case of carcinoma in situ arising from the long standing multiple fibroadenoma in a postmenopausal women. Clinical and radiological features are not helpful in identifying carcinoma arising from fibroadenoma. Histopathological examination of the excised specimen should be done for the confirmation of the diagnosis.

Malignant gastrointestinal stromal tumors (GISTs) of the duodenum – A rare occurrence: Case report.

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal (GI) tract. Most of the cases are located in the stomach followed by the small intestine. They arise from the interstitial cells of cajal, which are located in the wall of the intestine. Malignant GISTs are rare type of tumors in GIT. Small intestine GIST is more likely to be malignant compared to stomach. Here we reported such a rare case of malignant GIST in a 54 years old female patient who came to the hospital with complaints of pain and mass in abdomen. Ultrasound revealed a mass originating from the duodenum. Provisional clinical diagnosis of duodenal carcinoma was considered preoperatively. Patient underwent complete surgical excision of the tumor. Histopathological examination confirmed the diagnosis of malignant GIST. As the recurrence rate for malignant GIST is high, patient was kept on follow up.

Adenosquamous carcinoma of stomach: A rare entity – Case report.

Primary gastric adenosquamous carcinomas are rare and constitute less than 0.5% of all gastric malignancies. They are common in males and seen in sixth decade of life. These tumors are composed of both adenocarcinoma and squamous cell carcinoma in varied proportions. Here we have presented such a rare case in a 47 years old male patient who presented with complaints of abdominal pain and bleeding. Routine investigations were normal except for mild anemia. Upper gastrointestinal endoscopy revealed ulcerartive lesion in the pyloric antrum. Histopathological examination confirmed the diagnosis of adenosquamous carcinoma. They are aggressive tumors and have worse prognosis compared to adenocarcinomas hence, follow up is necessary.