ABSTRACT
Introduction: Hypertension represents a multifactorial disease of blood pressure (BP) regulation with persistently elevated systolic and/or diastolic BP over 140/90mmHg. 90% cases of hypertension have to be assigned as essential hypertension. Research has proven that patients with essential hypertension, especially at an early stage without any medication, display autonomic disturbance in the form of increase in sympathetic and a reduction in parasympathetic activity of the ANS. The heart rate variability analysis is a powerful tool in assessment of the cardiac autonomic nerve function. It is non-invasive, an accurate, reliable, reproducible, yet simple to measure and to process and It is indicative of neuro-cardiac fitness and overall health. Objective – The aim of the present study was to (1) measure Heart rate variability (HRV) in Essential Hypertension (2) effect of different drugs on Heart rate variability in hypertension among hypertensive subjects. Materials and Methods: This study was conducted On 100 Hypertension subjects & 100 Normal subjects after obtaining informed written consent by use of Heart rate variability Analysis System Variowin-HR Medical System. Results: The mean values of Very low frequency (VLF), Low frequency (LF), High frequency (HF), Normalized High Frequency (HF (nu) & all time domain parameters were found to be reduced significantly in hypertensive subjects as compared to control subjects. The mean values of LF (nu), LF / HF ratio were significantly high in hypertensive subjects as compared to control subjects. Conclusion: observations in our study demonstrate that hypertensive subjects had markedly reduced heart rate variability (HRV) in comparison with normal subjects which indicate cardiac autonomic disturbances in hypertension subjects in causation of essential hypertension.