ABSTRACT
A hypoplastic empty scrotum is a critical factor in the success of implantation of artificial testis. A hypoplastic scrotum increases the postoperative complication, such as wound dehiscence and prosthesis extrusion. Any technique cannot overcome this problem satisfactorily. Furthermore previous operative scars and inflammatory disease as epididymo-orchitis have often added to the difficulties. Enlarging the scrotum by gradual distention of a tissue expander implanted in the contracted scrotum has been successful in overcoming this problem. We report a case of successful artificial testes implantation after gradually enlarging scrotum by tissue expander in a 6 year old boy, who was diagnosed anorchidism with scrotal hypoplasia.
Subject(s)
Child , Humans , Male , Cicatrix , Postoperative Complications , Prostheses and Implants , Scrotum , Testis , Tissue Expansion Devices , Wounds and InjuriesABSTRACT
Prostate-specific antigen(PSA) in serum exists in several molecular forms that can be measured by immunodetectable assays; free PSA, PSA complexed to alpha1-antichymotripsin and total PSA, which represents the sum of the free and complexed forms. We have determined the amount and ratio of these forms may be seful for increasing the ability of PSA to be used in distinguishing prostate cancer(PCa) from benign prostatic hyperplasia(BPH). We evaluated 117 asymptomatic healthy male controls(mean age 55.8, range 50-71) with no clinical evidence of PCa, 125 men with symptomatic BPH(mean age 67.6, range 52-89) who underwent prostatic surgery(open prostatectomy or TLRP) and 14 men with biopsy-proven, untreated PCa(mean age 71.3 range 54-86). Using ACS-PSA2 assay(Ciba-Corning). we measured the free PSA(F), total PSA(T) and free/total(F/T) ratio. The method utilized was monoclonal-polyclonal immunometric, chemiluminescent assay, using a standardized calibrator 90:10. We also performed total PSA measurement with Tandem-R PSA assay(Hybritech). Correlation between ACS-PSA2 assay and Tandem-RPSA assay was excellent (r2=0.93). Receivr operating characteristics(ROC) analyses between them showed very similar performances. ROC analysis of free to total PSA ratio was more superior than that of free form PSA only. When all subjects were included, the ratio of free to total PSA in controls, BPH and PCa were 0.27, 0.24 and 0.07, respectively. which significantly differentiated between PCa and benign conditions(p<0.01). When the cut-off value (Fr) was set into 0.12, its diagnostic sensitivity and specificity were 86% and 84%, respectively. These findings suggest that free to total PSA ratio may enhance the ability to distinguish benign histologic conditions from cancer.
Subject(s)
Humans , Male , Luminescent Measurements , Passive Cutaneous Anaphylaxis , Prostate , Prostate-Specific Antigen , Prostatectomy , ROC Curve , Sensitivity and SpecificityABSTRACT
Recently developed International Prostate Symptom Score(I-PSS) is highly recommended for the evaluation of urinary symptoms in benign prostatic hyperplasia(BPH) and many linguistic translations have been made. English version of I-PSS was translated into Korean. Three groups of urologists and ordinary people participated for the translation and back-translation of I-PSS. A Korean version was finalized and translation validity was assessed by a survey with 48 English speaking Korean aged men. Test-retest reliability was confirmed by an another questionnaire survey with 76 aged men. Translation of I-PSS into Korean was valid. The I-PSS Korean version was internally consistent and sensitive as well as specific for the discrimination of symptomatic groups. Also test-retest reliability was acceptable.