ABSTRACT
Background@#The incidence of atopic dermatitis has been increasing and the condition is known to present with different phenotypes. As response to treatment varies from patient to patient, many attempts have been made to classify atopic dermatitis into different clinical phenotypes and endophenotypes to personalize treatment. @*Objective@#This is a pilot study that aims to classify atopic dermatitis into common clinical phenotypes and associate each of the phenotypes with clinical characteristics and laboratory findings. @*Methods@#A total of 186 adult atopic dermatitis patients were classified into four clinical phenotypes: lichenoid/exudative, nummular, prurigo-nodularis, and erythrodermic. We compared baseline characteristics, disease severity, laboratory test results, associated symptoms, and lesional location between the phenotypes. @*Results@#The age was lower, and proportion of very early onset group was higher in lichenoid/exudative type. Eczema Area and Severity Index score was significantly lower in nummular type patients. Total immunoglobulin E and eosinophilic cationic protein values were higher in lichenoid/exudative type patients and total immunoglobulin E and eosinophil (%) were lower in nummular type patients. In prurigo-nodularis type patients, eosinophilic cationic protein and vitamin D deficiency were frequent. Vitamin D deficiency was infrequent in erythrodermic type patients. @*Conclusion@#Lichenoid/exudative type patients showed classical characteristics of atopic dermatitis, and related to extrinsic type. In nummular type, patients tend to be more intrinsic and less severe. In prurigo-nodularis type, patients would be related to frequent vitamin D deficiency. Erythrodermic type patients showed more extensive atopic dermatitis lesions and less frequent vitamin D deficiency.
ABSTRACT
Eruptive xanthomatosis is a condition of extensive yellowish papules and nodules with fat deposits which can spread systemically. Although eruptive xanthomatosis is usually related to abnormal lipid metabolism, few cases have been reported in patients with normal lipid levels. The current treatment option is treatment of dyslipidemia by lifestyle modification and lipid-lowering agents. But treatment strategies in normolipidemia patients have not been established. Herein, we report an unusual case of eruptive xanthomatosis in normolipidemia patient showing clinical improvement after narrow-band ultraviolet B therapy
ABSTRACT
There have been a few cases of alopecia areata (AA) patients with pityriasis rubra pilaris (PRP), but the relationship between them is unclear. To the best of our knowledge, there have been no cases of co-occurrence reported in Korea. A 58-year-old male presented with multiple erythematous follicular papules and scaly plaques on the both legs with diffuse keratotic thickening on both palms and soles for several months. After skin biopsy, he was diagnosed with type I PRP. After treatment with oral and topical steroid, vitamin D3 analogue, oral alitretinoin, and urea cream for one week, multiple, diffuse alopecic patches appeared. He was diagnosed with AA after skin biopsy and we added topical minoxidil. Herein, we report a case of AA in a patient with type I PRP.
ABSTRACT
Eruptive xanthomatosis is a condition of extensive yellowish papules and nodules with fat deposits which can spread systemically. Although eruptive xanthomatosis is usually related to abnormal lipid metabolism, few cases have been reported in patients with normal lipid levels. The current treatment option is treatment of dyslipidemia by lifestyle modification and lipid-lowering agents. But treatment strategies in normolipidemia patients have not been established. Herein, we report an unusual case of eruptive xanthomatosis in normolipidemia patient showing clinical improvement after narrow-band ultraviolet B therapy
ABSTRACT
There have been a few cases of alopecia areata (AA) patients with pityriasis rubra pilaris (PRP), but the relationship between them is unclear. To the best of our knowledge, there have been no cases of co-occurrence reported in Korea. A 58-year-old male presented with multiple erythematous follicular papules and scaly plaques on the both legs with diffuse keratotic thickening on both palms and soles for several months. After skin biopsy, he was diagnosed with type I PRP. After treatment with oral and topical steroid, vitamin D3 analogue, oral alitretinoin, and urea cream for one week, multiple, diffuse alopecic patches appeared. He was diagnosed with AA after skin biopsy and we added topical minoxidil. Herein, we report a case of AA in a patient with type I PRP.
ABSTRACT
Colorectal perineuriomas are benign mucosal-based mesenchymal tumors composed of perineurial cells and show serrated or hyperplastic crypts in epithelium on histopathological evaluation. Most perineuriomas are usually presented as sessile polyps and often as subepithelial tumors. In this case, colonoscopy revealed a rectal subepithelial tumor (measuring approximately 7 mm) with yellowish-colored normal mucosa. A rectal neuroendocrine tumor was suspected, and cap-assisted endoscopic mucosal resection was performed. Histopathological examination of the resected specimen revealed bland spindle cells showing immunopositivity for CD34.The patient was finally diagnosed with rectal perineurioma
ABSTRACT
Acroangiodermatitis is a rare, self-limiting, angioproliferative disorder associated with congenital vascular malformations or acquired venous insufficiency. The clinical features of acroangiodermatitis are notably similar to those of Kaposi sarcoma, making it difficult to differentiate between the two diseases. A 57-year-old male patient presented with multiple violaceous to black, crusted, indurated plaques with ill-defined margins on both swollen lower legs. A venous Doppler study of the bilateral lower limbs was unremarkable. A histopathological examination showed a hyperplastic epidermis, a prominent proliferation of small dilated vessels lined by plump endothelial cells in the dermis, hemosiderin deposits, and lymphocytic infiltrate around vessels. Immunohistochemical analysis showed CD31＋ and podoplanin＋ staining in endothelial cells.
ABSTRACT
Acroangiodermatitis is a rare, self-limiting, angioproliferative disorder associated with congenital vascular malformations or acquired venous insufficiency. The clinical features of acroangiodermatitis are notably similar to those of Kaposi sarcoma, making it difficult to differentiate between the two diseases. A 57-year-old male patient presented with multiple violaceous to black, crusted, indurated plaques with ill-defined margins on both swollen lower legs. A venous Doppler study of the bilateral lower limbs was unremarkable. A histopathological examination showed a hyperplastic epidermis, a prominent proliferation of small dilated vessels lined by plump endothelial cells in the dermis, hemosiderin deposits, and lymphocytic infiltrate around vessels. Immunohistochemical analysis showed CD31＋ and podoplanin＋ staining in endothelial cells.
ABSTRACT
Laryngeal schwannoma is extremely rare. We report the CT and MRI findings of a case occurring in a 65-year-oldwoman, and describe the pathologic correlation. Pre-contrast CT scanning revealed a right supraglot-tic mass witha slightly hyperdense central part and a hypodense peripheral part. Post-contrast CT scanning re-vealed anenhanced hyperdense central part and a rim-like hypodense peripheral part. The density of the pe-ripheral part waslower than that of muscle. The mass showed homogeneous low signal intensity on T1-weighted MR images, homogeneoushigh signal intensity on T2-weighted MR images, and an enhanced high signal intensity central part and a lowsignal intensity peripheral part on gadolinium enhanced T1-weighted images. The enhanced central part correlatedwith Antoni A areas and the peripheral part, showing low attenuation, correlated with Antoni B areas.