ABSTRACT
Objective To explore the risk factors for persistent pulmonary hypertension of the newborns (PPHN).Methods An 1 ∶ 1 matched case-control study was conducted in 41 cases of PPHN.Chi-square,t-test or ANOVA were used to perform univariate analysis.All factors for P values less than 0.05 were used as independent variables for multivariate analysis of Logistic regression,and a predictive model of Logistic regression for the genesis of PPHN was established,and the model was evaluated preliminarily.Results By multivariate analysis of Logistic regression,meconium aspiration syndrome (OR =52.391,95 ％ CI:3.899-703.959),matemal diabetes (OR =49.758,95 ％ CI:3.544-698.686),neonatal pneumonia (OR =49.637,95％ CI:6.143-401.100),intra-uterine growth restriction (OR =26.666,95％ CI:2.997-237.282),hyaline membrane disease (OR =15.200,95 ％ CI 2.862-80.726) were significantly related to genesis of PPHN.Goodness of fit for predictive model of Logistic regression was checked by Chisquare and x2 value was 23.681.It indicated model check was statistically significant (P ＜ 0.01).Conclusions Meconium aspiration syndrome,maternal diabetes,neonatal pneumonia,intra-uterine growth restriction,and hyaline membrane disease are major risk factors for genesis of PPHN.
ABSTRACT
OBJECTIVE@#To observe the alteration of nestin intervals in the experimental traumatic brain injury and investigate its relation to the injury intervals.@*METHODS@#The rat brain contusion was conducted by falling impact injury. After various survival interval (0.5, 6, 12 h and 1, 3, 7, 14, 28 d), immunohistochemical SP method was used for observing the expression of nestin in the cortex, hippocampal dentate gyrus and the corpus callosum on injury side.@*RESULTS@#Expression of nestin positive cells increased at 0.5 h and reached the maximum level in 7 d after brain contusion, then the expression decreased gradually. The intensity of nestin staining in the the cortex and the hippocampal dentate gyrus decreased to normal on 28 d. As to the corpus callosum of injury side it remained weak on 28 d.@*CONCLUSION@#The changes of nestin immunohistochemical staining can be used as an index for forensic estimation of early injury time.