ABSTRACT
Objective: To explore the effect of low-dose Maren Soft Capsule (MSC) on constipation and colonic mucosa. Methods: Patients (208 cases) with colon slow transit constipation and mixed constipation were divided into treatment and control groups. MSC (two pills, once daily) and Sennae Folium (5 g) were given to the patients in the treatment and control groups, respectively, for 10 months. The recovery rate, total significant efficiency, and total efficiency were determined by defecation frequency and gastrointestinal transmission experiment. The side effects such as bloating and abdominal pain were observed. Results: The recovery rate in the treatment group was lower than that in the control group, and the total significant efficiency and total efficiency were similar to those in the control group. There was no colon melanosis in the treatment group after 10 month, while 26.9% of the patients in the control group were observed with colon melanosis. Conclusion: The low-dose MSC has the therapeutic effect on constipation with high safety.
ABSTRACT
<p><b>OBJECTIVE</b>To search for the best therapy for slow transmission constipation (STC) or mixed constipation (MC) by intensive acupoints thread embedding (IATE).</p><p><b>METHODS</b>A total of 310 patients with constipation were assigned to 5 groups using a stratification control method. The 62 patients of STC in the observation group I were treated by IATE at Dachangshu (BL 25), Tianshu (ST 25), Zhongji (CV 3) and Zusanli (ST 36) acupoints; the 62 of MC in the observation group II by IATE at the same acupoints and local anal operation; both the 62 of STC in the control group I and the 62 of MC in the control group 1I were treated by oral administration of Simo Decoction, while the 62 of MC in the control group III were treated by local anal operation alone. Conditions of defecation were recorded every day in the 6-month follow-up period. Gastrointestinal transit test (GITT) was carried out before and after treatment. One follow-up was conducted at the 1st, 3rd and 6th month.</p><p><b>RESULTS</b>In the 124 patients of the two observation groups, 52 (41.9%) were cured after treatment, they could normally discharge stool, 5 (4.0%) showed markedly effective with their constipation alleviated, but having occasional bowel slackened sensation. In the control group I and II, none was cured or effectively treated, while in the control group III, the efficacy in 8 patients were judged as marked effective, but none was cured.</p><p><b>CONCLUSION</b>IATE is a convenient and effective composite therapy. It shows favorable clinical efficacy for STC, and also for MC in case of combined with local anal operation.</p>