Preferred thrombectomy strategies for acute embolic occlusion of the vertebrobasilar artery: a comparative study / 中华神经医学杂志

Objective:To investigate the efficacy of different preferred thrombectomy strategies for embolic acute vertebrobasilar artery occlusion (AVBAO).Methods:Forty-four patients with embolic AVBAO who underwent endovascular treatment in Department of Neurology, Nanyang Central Hospital from January 2019 to June 2021 were included in the study. Patients were divided into stent-retriever thrombectomy group ( n=27) and aspiration thrombectomy group ( n=17) according to different preferred thrombectomy strategies. Modified Rankin scale (mRS) was used to evaluate the prognoses of these patients 90 d after surgery; the differences of clinical data, surgery-related characteristics, prognoses and complications between the two groups were compared. Results:There was no significant difference between the 2 groups in terms of time from onset to puncture, sites of target vessel occlusion, proportion of patients accepted intraoperative remedial measures, and successful recirculation rate of target vessels ( P>0.05). Compared with the aspiration thrombectomy group, the stent-retriever thrombectomy group had significantly decreased utilization rate of middle catheters, significantly increased retrieval attempts in thrombectomy, statistically lower re-recanalization rate of first-time thrombectomy on the target vessels, significantly longer time from puncture to re-recanalization, and significantly higher incidence of new embolism ( P<0.05). There was no significant difference between the 2 groups in incidences of vascular rupture and postoperative spontaneous intracerebral hemorrhage (sICH), and good prognosis rate 90 d after surgery ( P>0.05). Conclusion:For embolic AVBAO patients, similar recanalization and short-term good prognosis can be obtained by aspiration thrombectomy to those by stent-retriever thrombectomy; besides that, aspiration thrombectomy has advantages as shorter recanalization time, less new embolic complications and higher re-recanalization rate of first-time thrombectomy.

Effects of ATP and ATP-MgCl_2 administration in hemorrhagic shock / 中国病理生理杂志

The therapeutic effect of ATP and ATP-MgCl_2 on hemorrhagic shock in large doses was studied. The hybrid dogs, male or female, were divided into three groups at random. The effects of ATP and ATP-MgCl_2 on antihemorrhagic shock was analized during its various stages by standards of capillary blood velocity, the number of capillary blood vessels in activity, artery blood pressure, the acidity of arterial blood and changes of sensitivity of the reflex of sinus arteriae carotidis. The results indicated that the therapeutic effect of ATP-MgCl_2 in large dose is much superior to that of ATP.