ABSTRACT
Objective To investigate the clinical efficacy of atomization inhalation combined with montelukast in the treatment of children with post infectious cough.Methods From January 2016 to January 2018,100 children with post-infection cough were selected and randomly divided into two groups according to the digital table,with 50 cases in each group.The observation group was treated with oral budesonide atomization inhalation.The control group was not given drugs.The clinical efficacy,symptom score,pulmonary function index,inflammatory factor index and adverse reaction were compared between the two groups.Results The total effective rate in the observation group was higher than that in the control group [96％ (48/50) vs.80％ (40/50),P ＜ 0.05].After treatment,the scores of daytime cough,nocturnal cough and expectoration in both two groups were lower than those before treatment (all P ＜0.05),which in the observation group were lower than those in the control group(all P ＜ 0.05).After treatment,the two pulmonary function indicators of FEV1,FEV1/FVC in the observation group were higher than those in the control group(all P ＜ 0.05),and the inflammatory cytokines such as CRPIL-6,TNF-α in the observation group were lower than those in the control group(all P ＜ 0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups [6％ (3/50) 比 4％ (2/50),P ＞ 0.05].Conclusion The combination of oral montelukast and budesonide atomization inhalation can effectively treat children with cough after infection,relieve their symptoms,improve the lung function,suppress the inflammatory reaction of respiratory tract,and it is safe and reliable.
ABSTRACT
Objective@#To investigate the clinical efficacy of atomization inhalation combined with montelukast in the treatment of children with post infectious cough.@*Methods@#From January 2016 to January 2018, 100 children with post-infection cough were selected and randomly divided into two groups according to the digital table, with 50 cases in each group.The observation group was treated with oral budesonide atomization inhalation.The control group was not given drugs.The clinical efficacy, symptom score, pulmonary function index, inflammatory factor index and adverse reaction were compared between the two groups.@*Results@#The total effective rate in the observation group was higher than that in the control group[96%(48/50) vs.80%(40/50), P<0.05]. After treatment, the scores of daytime cough, nocturnal cough and expectoration in both two groups were lower than those before treatment(all P<0.05), which in the observation group were lower than those in the control group(all P<0.05). After treatment, the two pulmonary function indicators of FEV1, FEV1/FVC in the observation group were higher than those in the control group(all P<0.05), and the inflammatory cytokines such as CRPIL-6, TNF-α in the observation group were lower than those in the control group(all P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups[6%(3/50)比4%(2/50), P>0.05].@*Conclusion@#The combination of oral montelukast and budesonide atomization inhalation can effectively treat children with cough after infection, relieve their symptoms, improve the lung function, suppress the inflammatory reaction of respiratory tract, and it is safe and reliable.