ABSTRACT
This study was aimed to explore regulatory mechanism of TRPV1 and related cytokines on children bronchial asthma and to study regulation of traditional Chinese medicine (TCM) on TRPV 1 and its related cytokines.Through KEGG database combined with literature search,the preliminary regulatory network of children bronchial asthma was drawn.And regarding the key nodes in the network,literature and database searches on related TCM were conducted.The results showed that the preliminary regulatory network was mapped out through KEGG database in combination with previous researches and literature search.Currently,studies had shown that emodin,baicalin,corydalis ambigua and dragon's blood had different degrees of downregulation effect on TRPV1.Yi-Shen Ping-Chuan Huo-Xue (YSPCHX)mixture suppresses the level of cytokine IL-2 and improves the level of cytokine IL-4 in a dose-dependent manner;astragalus mongholicus regulates the ratio of Th 1 to Th2,and Chuan-Fu-Ling (CFL) plaster elevates the level of IFN-γ.And both of them reduced the level of IL-4 in serum.It was concluded that the preliminary regulatory network of children bronchial asthma in this study provided certain basis for the regulatory mechanism of children bronchial asthma and treatment in TCM