Toxicity of chitin and chitosan

Chitin is a natural product while chitosan is synthetic product from chitin. A study on the activity of chitin and chitosan in dogs has shown that the use of intradermal chitosan at dose of 200 mg/kg killed all experimental dogs because of pulmonary hemorrhage while this dose of chitin did not kill any dogs. Until now, it was limited to use chitin and chitosan in human as a food complementary, anti obesity and scar healing.